Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol KCTD6 contributors: mct - updated : 13-03-2014
HGNC name potassium channel tetramerisation domain containing 6
HGNC id 22235
Location 3p14.3      Physical location : 58.477.822 - 58.488.085
Synonym name
  • BTB/POZ domain-containing protein KCTD6
  • KCTD containing, Cullin3 adaptor, suppressor of Hedgehog 3
  • Synonym symbol(s) MGC27385, KCASH3
    DNA
    TYPE functioning gene
    STRUCTURE 10.26 kb     3 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 1566 - 237 - 2012 22573887
    2 - 1840 - 237 - 2012 22573887
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrainhindbraincerebellumcerebellar cortexhighly Homo sapiens
    Reproductivemale systemprostate   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticerythrocyte Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a K+ channel tetramerisation domain
  • a BTB domain required for the formation of a Cullin3 ubiquitin ligase complex and HDAC1 ubiquitination and degradation capability
  • mono polymer heteromer , tetramer , complex
    HOMOLOGY
    interspecies homolog to murine Kctd6
    Homologene
    FAMILY potassium channel tetramerization domain (KCTD) family
    CATEGORY transport
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • may have a voltage-gated K+ channel activity
  • acts through ubiquitination-dependent degradation of HDAC1, thereby affecting Hh activity and medulloblastoma growth
  • OBSCN and KCTD6 regulate cullin-dependent small ankyrin-1 (ANK1) protein turnover
  • involved in the turnover of the muscle small ankyrin-1 isoform 5 and, in combination with KCTD11, in the ubiquitination and degradation of HDAC1
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to K+ channel proteins to form a complex
  • interaction of KCTD6 with ANK1 may have implications beyond muscle for hereditary spherocytosis, as KCTD6 is also present in erythrocytes, and erythrocyte ankyrin isoforms contain its mapped minimal binding site
  • KCTD6(BTB) and KCTD11(BTB) bind CUL3 with high affinity forming stable complexes with 4:4 stoichiometries
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS