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FLASH GENE
Symbol KCTD10 contributors: SGE/npt - updated : 12-07-2013
HGNC name potassium channel tetramerisation domain containing 10
HGNC id 23236
Location 12q24.11      Physical location : 109.886.459 - 109.915.155
Synonym name
  • MSTP028 protein
  • BTB/POZ domain-containing protein KCTD10
  • Synonym symbol(s) MSTP028, FLJ41739, ULRO61
    DNA
    TYPE functioning gene
    STRUCTURE 28.70 kb     7 Exon(s)
    regulatory sequence Promoter
    cytosine-phosphate-guanine/HTF
    Binding site   enhancer   silencer
    text structure
  • a CpG island near to the transcription start site in the promoter (Liu 2009)
  • a SP1 and AP2 binding sites (Liu 2009)
  • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 4057 - 313 - Zhou (2005)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularvesselsaorta   
    Digestiveesophagus   highly
     mouth   highly
    Respiratoryrespiratory tracttrachea  highly
    Visualeye    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one BTB (POZ) domain
  • conjugated PhosphoP
    mono polymer heteromer , tetramer
    HOMOLOGY
    interspecies homolog to murine Kctd10 (98.4pc)
    intraspecies homolog to PDIP1
    Homologene
    FAMILY
  • polymerase delta-interacting protein 1 (PDIP1) gene family
  • KCTD10/KCTD13/TNFAIP1 family
  • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • K+ channel activity
  • may be associated with DNA synthesis and cell proliferation (Wang 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text potassium ion transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • can interact with the small subunit of DNA polymerase delta and PCNA (Wang 2009)
  • TNFAIP1 overexpression resulted in ubiquitin-mediated degradation of KCTD10 proteins
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism other
  • KCTD10 (V206VT->C and i5642G->C) variants may contribute to the variation in HDL-cholesterol concentrations, particularly in subjects with high carbohydrate intakes (Junyent 2009)
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS