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FLASH GENE
Symbol KCNV1 contributors: - updated : 21-09-2005
HGNC name potassium channel, subfamily V, member 1
HGNC id 18861
Location 8q22.3-q24.1      Physical location : 110.979.234 - 110.986.959
Synonym name
  • neuronal potassium channel alpha subunit
  • voltage-gated potassium channel Kv8.1
  • Synonym symbol(s) HNKA, KV8.1, KV2.3, KCNB3
    DNA
    TYPE functioning gene
    STRUCTURE 7.00 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    Binding site
    text structure
  • 5' noncoding exon, which extended the reported cDNA sequence to approximately 600 bp.
  • three Sp1 motifs were found to be active in the core promoter sequence
  • MAPPING cloned Y linked N status provisional
    Physical map
    LOC346887 8q23.1 similar to hypothetical protein FLJ30794 OXR1 8q23 oxidation resistance 1 STARS 8q23.1 striated muscle activator of Rho-dependent signaling ANGPT1 8q22.3-q23 angiopoietin 1 MGC35555 8q23.1 hypothetical protein MGC35555 LOC389681 8 similar to nuclear receptor binding factor-2; comodulator of PPAR and RXR EIF3S6 8q22-q23 eukaryotic translation initiation factor 3, subunit 6 48kDa LOC392260 8 similar to dJ753D5.2 (novel protein similar to RPS17 (40S ribosomal protein S17)) KIAA0103 8q23.2 KIAA0103 FLJ30668 8q23.2 hypothetical protein FLJ30668 TRHR 8q23 thyrotropin-releasing hormone receptor CML66 8q23 chronic myelogenous leukemia tumor antigen 66 DC6 8q23.2 DC6 protein PKHD1L1 8q23.2 polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1 MAPK6PS5 8q23 polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1 EBAG9 8q23.3 estrogen receptor binding site associated, antigen, 9 FLJ20366 8q23.2 hypothetical protein FLJ20366 LOC392261 8 similar to hypothetical protein A930017M01 KCNV1 8q22.3-q24.1 potassium channel, subfamily V, member 1 LOC392262 8 similar to laminin-binding protein CSMD3 8q23.3 CUB and Sushi multiple domains 3
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   highly
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoietic    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • six putative membrane-spanning domains
  • an hydrophobic pore including the P domain with the K+ channel signature, flanked by TM domains 5 and 6, sensitive to changes in membrane potential
  • a C terminal splice variants that inserts 19 amino acids with a consensus protein kinase C phosphorylation site after the last membrane-spanning segment
  • HOMOLOGY
    Homologene
    FAMILY
  • potassium channel family
  • b (shab) subfamily
  • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION inhibiting the expression of Shaw channels
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS