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FLASH GENE
Symbol KCNV1 contributors: - updated : 21-09-2005
HGNC name potassium channel, subfamily V, member 1
HGNC id 18861
Location 8q22.3-q24.1      Physical location : 110.979.234 - 110.986.959
Synonym name
  • neuronal potassium channel alpha subunit
  • voltage-gated potassium channel Kv8.1
    • Synonym symbol(s) HNKA, KV8.1, KV2.3, KCNB3
    DNA
    TYPE functioning gene
    STRUCTURE 7.00 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    Binding site
    text structure
  • 5' noncoding exon, which extended the reported cDNA sequence to approximately 600 bp.
  • three Sp1 motifs were found to be active in the core promoter sequence
    • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   highly
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoietic    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • six putative membrane-spanning domains
  • an hydrophobic pore including the P domain with the K+ channel signature, flanked by TM domains 5 and 6, sensitive to changes in membrane potential
  • a C terminal splice variants that inserts 19 amino acids with a consensus protein kinase C phosphorylation site after the last membrane-spanning segment
    • HOMOLOGY
    Homologene
    FAMILY
  • potassium channel family
  • b (shab) subfamily
    • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION inhibiting the expression of Shaw channels
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS