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FLASH GENE
Symbol KCNU1 contributors: mct - updated : 08-03-2010
HGNC name potassium channel, subfamily U, member 1
HGNC id 18867
Location 8p11.23      Physical location : 36.641.841 - 36.793.641
Synonym name
  • slowpoke homolog 3
  • calcium-activated potassium channel, subfamily M subunit alpha-3
  • Synonym symbol(s) Kca5.1, Slo3, KCNMC1, Kcnma3, Kca5
    DNA
    TYPE functioning gene
    STRUCTURE 151.80 kb     27 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    27 - 3756 129 1149 - -
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis  specific
    cell lineage
    cell lines
    fluid/secretion exclusively expressed in mammalian sperm
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one RCK N-terminal domain
  • mono polymer homomer , tetramer
    HOMOLOGY
    Homologene
    FAMILY
  • potassium channel family
  • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • involved in potassium ion transport
  • responsible for the capacitation-induced hyperpolarization of the membrane and thus is crucial for the acrosome reaction, playing a role n male fertility (Santi 2010)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS facilitated diffusion transport
    PATHWAY
    metabolism
    signaling
    a component
  • homotetramer constituting the Ca2+-activated potassium channel
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • opens upon intracellular pH increase and its expression and functional properties are modulated by LRRC52, a testis-specific accessory subunit
  • cell & other
    REGULATION
    activated by both intracellular pH and membrane voltage, thus mediating export of K+
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS