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FLASH GENE
Symbol KCNS2 contributors: npt/ - updated : 17-08-2007
HGNC name potassium voltage-gated channel, delayed-rectifier, subfamily S, member 2
HGNC id 6301
Location 8q23.3-q24.11      Physical location : 99.439.249 - 99.443.021
Synonym name
  • delayed-rectifier K(+) channel alpha subunit 2
  • voltage-gated potassium channel subunit Kv9.2
    • Synonym symbol(s) KV9.2, KIAA1144
    DNA
    TYPE functioning gene
    STRUCTURE 3.77 kb     2 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map cen - D8S1122 - D8S1960 - D8S1625 - KCNV1 - KCNS2 - D8S130 - D8S1482 - D8S1470 - D8S65 - D8S1202 - D8S49 - D8S588 - D8S1204 - D8S539 - D8S1139 - D8S555 - D8S1142 - D8S281 - D8S42 - D8S50 - D8S565 - D8S547 - D8S1200 - D8S51 - D8S1201 - D8S1216 - qter
    Authors Hilton (01)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 3219 54 477 - Salinas (1997)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrainforebraincerebral cortex  
     braindiencephalonhypothalamus  
     brainhindbraincerebellum  
     spinal cord    
    Olfactoryolfactory bulb    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelial    
    Nervouscentral   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • six putative membrane-spanning domains
  • an hydrophobic pore including the P domain with the K+ channel signature
  • TM domains 5 and 6, sensitive to changes in membrane potential
  • a putative phosphorylation sites
    • HOMOLOGY
    Homologene
    FAMILY
  • potassium channel family
  • subfamily Shab
    • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • modulator of Kv2.1,Kv2.2 of Kv2.1 (KCNB1), KU2.2 (KCNB2)
  • potassium voltage-gated channel delayed-rectifier
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS