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FLASH GENE
Symbol KCNRG contributors: SGE/npt - updated : 19-02-2010
HGNC name potassium channel regulator
HGNC id 18893
Location 13q14.2      Physical location : 50.589.389 - 50.595.057
Synonym name protein DELTET
Synonym symbol(s) DLTET, CLLD4, RP11-34F20.6
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
STRUCTURE 5.67 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Map cen - D13S1150 - RFP2 - KCNRG - DLEU2 - DLEU1 - D13S319 - qter
Authors Ivanov et al. (03)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 1527 31 272 - Ivanov et al. (03)
  • isoform 1
  • 3 splicing 1625 25 229 only in the cytoplasm Ivanov et al. (03)
  • variant lacking exon 2
  • isoform 2
  • EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivestomach   lowly
    Nervousbrain   lowly
    Reproductivemale systemprostate   
    Respiratorylung    
    Urinarykidney   lowly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymhoid/Immunelymphocyte
    cell lineage
    cell lines colon carcinoma, epidermal carcinoma, breast cancer, osteogenic sarcoma
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES globular
    STRUCTURE
    motifs/domains
  • a K+ channel tetramerisation domain
  • one B box-type zinc finger
  • one RING-type zinc finger
  • conjugated PhosphoP
    mono polymer heteromer , tetramer
    HOMOLOGY
    interspecies ortholog to murine Kcnrg
    ortholog to rattus Kcnrg_predicted
    Homologene
    FAMILY
  • TRIM/RBCC family
  • CATEGORY regulatory , tumor suppressor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    text soluble protein
    basic FUNCTION
  • might interfere with normal assembly of K+ channel proteins and inhibit their activity by binding to their tetramerisation domain
  • may act as a tumor suppressor
  • inhibits potassium fluxes in cells
  • ER-associated protein which may regulate Kv1 family channel proteins by retaining a fraction of channels in endomembranes (Usman 2010)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text potassium ion transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+ binding
  • protein
  • binding to voltage-gated K+ channels
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • for a B-cell chronic lymphocytic leukemia and prostate cancer tumor suppressor gene
  • may be a bronchial autoantigen involved in APS-1 (Alimohammadi 2009)
  • involved in tumorigenesis of HCC (Cho 2006)
  • Marker
    Therapy target
    ANIMAL & CELL MODELS