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FLASH GENE
Symbol KCNN4 contributors: mct - updated : 25-08-2015
HGNC name potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
HGNC id 6293
Corresponding disease
DHS2 dehydrated hereditary stomatocytosis 2
Location 19q13.31      Physical location : 44.270.686 - 44.285.409
Synonym name
  • putative Gardos channel
  • intermediate conductance calcium-activated potassium channel protein
  • 1
    Synonym symbol(s) SKCA4, IKCA1, hKCa4, IK1, SK4, KCA4, hSK4, KCa3.1, hIKCa1
    DNA
    TYPE functioning gene
    STRUCTURE 14.73 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map cen - [D19S197 - D19S211 - D19S408 - (XRCC1 - PLAUR - KCNN4 ) - D19S217- D19S178 ] - KCNA7 ,GYS1 - D19S604 - KCNC3 - D19S246 - qter
    Authors Ghanshani (98)
    Text [ ]:deleted in Diamond-Blackfan anemia
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 2240 47.6 427 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   moderately
     intestine   highly Homo sapiens
    Endocrinepancreas   highly
    Lymphoid/Immunespleen    
    Reproductivefemale systemuteruscervix moderately
     female systemplacenta  predominantly
     male systemprostate  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    Connectivebone  moderately
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Digestiveepithelial cell Homo sapiens
    Lymphoid/Immunelymphocyte
    cell lineage
    cell lines ovarian tumors
    fluid/secretion moderately in lymph
    at STAGE
    physiological period fetal, pregnancy
    Text liver, placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • six putative transmembrane domains
  • a conserved porc region
  • a leucine zipper-like motif near the C terminus
  • mono polymer heteromer , tetramer
    HOMOLOGY
    interspecies homolog to rattus Kcnn4 (85.8 pc)
    homolog to murine Kcnn4 (87.5 pc)
    Homologene
    FAMILY
  • SK channel family
  • potassium channel KCNN family
  • CATEGORY immunity/defense , transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • multi-pass membrane protein
  • KCNN4 channels in the apical membrane of intestinal epithelial cells
  • basic FUNCTION
  • acting as a voltage-independent potassium channel
  • plays an important role in T lymphocyte Ca(2+) signaling by helping to maintain a negative membrane potential, which provides an electrochemical gradient to drive Ca(2+) influx
  • involved in lung dendritic cells migration to lymphatic chemokines
  • KCNN4 channel in the apical and basolateral membranes of epithelial cells play important roles in agonist-induced fluid secretion in intestine and colon
  • plays a key role in human fibrocyte migration
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development , immunity/defense
    text K+ transport
    PATHWAY
    metabolism
    signaling
    a component
  • heterotetramer of potassium channel proteins
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to calmodulin
  • functional link between KCNN4 and PRKAG1 (regulation of KCNN4 by AMPK in a functional epithelium through protein/protein interactions)
  • time-dependent association between KCNN4 and USP8 following endocytosis
  • both PI3KC2B and TRIM27 play critical but opposite roles in FCER1A-stimulated activation of KCNN4, Ca2+ influx, degranulation, and cytokine production in bone marrow mast cells
  • by dephosphorylating NME2, PGAM5 negatively regulates CD4(+) T cells by inhibiting NME2-mediated histidine phosphorylation and activation of the KCNN4
  • cell & other
    REGULATION
    activated by intracellular calcium
    induced by phorbol myristate acetate (PMA) and phytohemagglutinin (PHA) in T-cells
    Other blocked by clotrimazole and charybdotoxin
    ASSOCIATED DISORDERS
    corresponding disease(s) DHS2
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in pancreas and ovarian tumors
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    allergyasthm 
    currently available KCNN4 blockers might therefore attenuate tissue fibrosis and remodeling in patients with diseases such as idiopathic pulmonary fibrosis and asthma through the inhibition of fibrocyte recruitment
    immunologyautoimmunedigestive
    it may be possible to rapidly test whether KCa3.1 inhibitors are efficacious in patients with inflammatory bowel diseases such as Crohn disease and ulcerative colitis
    cardiovascularatheroma 
    CKCNN4 blockers represent a promising therapeutic strategy for atherosclerosis.
    miscelleaneousurinarychronic kidney disease
    pharmacological inhibitors of KCNN4 channels may provide a novel and effective therapy to delay progression to kidney failure in patients with ADPKD
    ANIMAL & CELL MODELS