Selected-GenAtlas references | SOURCE | GeneCards | NCBI Gene | Swiss-Prot | Ensembl |
HGNC | UniGene | Nucleotide | OMIM | UCSC |
Home Page |
FLASH GENE |
Symbol | KCNN4 | contributors: mct - updated : 25-08-2015 |
HGNC name | potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4 |
HGNC id | 6293 |
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Corresponding disease |
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Location | 19q13.31 Physical location : 44.270.686 - 44.285.409 | ||
Synonym name | |||
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1 | |||
Synonym symbol(s) | SKCA4, IKCA1, hKCa4, IK1, SK4, KCA4, hSK4, KCa3.1, hIKCa1 |
DNA |
TYPE | functioning gene |
STRUCTURE | 14.73 kb 9 Exon(s) |
10 Kb 5' upstream gene genomic sequence study |
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MAPPING | cloned | Y | linked | N | status | confirmed |
Map | cen - [D19S197 - D19S211 - D19S408 - (XRCC1 - PLAUR - KCNN4 ) - D19S217- D19S178 ] - KCNA7 ,GYS1 - D19S604 - KCNC3 - D19S246 - qter |
Authors | Ghanshani (98) |
Text | [ ]:deleted in Diamond-Blackfan anemia |
RNA |
TRANSCRIPTS | type | messenger |
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EXPRESSION |
Type |
tissue |
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cells |
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cell lineage
cell lines
| ovarian tumors | fluid/secretion
| moderately in lymph | |
at STAGE |
physiological period | fetal, pregnancy |
Text | liver, placenta |
PROTEIN |
PHYSICAL PROPERTIES
STRUCTURE
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motifs/domains
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mono polymer | heteromer , tetramer |
HOMOLOGY |
interspecies | homolog to rattus Kcnn4 (85.8 pc) |
homolog to murine Kcnn4 (87.5 pc) |
Homologene |
FAMILY | |
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CATEGORY | immunity/defense , transport channel |
SUBCELLULAR LOCALIZATION | plasma membrane |
text | |
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basic FUNCTION | |
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CELLULAR PROCESS |
PHYSIOLOGICAL PROCESS | development , immunity/defense |
text | K+ transport |
PATHWAY |
metabolism |
signaling |
a component |
INTERACTION |
DNA |
RNA |
small molecule |
protein | |
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cell & other |
REGULATION |
activated by | intracellular calcium |
induced by | phorbol myristate acetate (PMA) and phytohemagglutinin (PHA) in T-cells |
Other | blocked by clotrimazole and charybdotoxin |
ASSOCIATED DISORDERS |
corresponding disease(s) | DHS2 |
Other morbid association(s) |
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Susceptibility |
Variant & Polymorphism
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Candidate gene
Marker
| Therapy target
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ANIMAL & CELL MODELS |