Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol KCNN2 contributors: mct - updated : 09-01-2012
HGNC name potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
HGNC id 6291
Location 5q22.3      Physical location : 113.698.015 - 113.832.196
Synonym name small conductance calcium-activated potassium channel protein 2
Synonym symbol(s) SK2, HSK2, SKCA2, KCa2.2
DNA
TYPE functioning gene
STRUCTURE 134.18 kb     8 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 initiation site 2515 63.8 579 in CA1 pyramidal neurons and likely form heteromeric channels with SK2S 2011 21602822
  • SK2-long (SK2-L)
  • differ only from SK2S in the length of their N-terminal domains
  • directs synaptic SK2-containing channel expression and is important for normal synaptic signaling, plasticity and learning
  • 6 initiation site 1457 - 231 brain, liver, in CA1 pyramidal neurons and likely form heteromeric channels with SK2L 2011 21602822
  • SK2-short (SK2-S)
  • differ only from SK2L in the length of their N-terminal domains
  • EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheartatrium    Homo sapiens
    Digestiveliver    
    Hearing/Equilibriumearinnercochlea   Homo sapiens
    Nervousbrain    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier/liningepidermisstratum basale 
    Muscularstriatumcardiac   Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Hearing / Equilibriumhair cell receptor Homo sapiens
    Muscularmyocyte Homo sapiens
    Skin/Tegumentmelanocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text heart
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • seven transmembrane domains the sixth (H5) being the pore forming domain
  • calmodulin binding domain
  • conjugated PhosphoP
    mono polymer heteromer , oligo
    HOMOLOGY
    interspecies ortholog to murine Kcnn2
    homolog to Drosophila SK
    homolog to C.elegans C03F11.1
    Homologene
    FAMILY KCNN family of potassium channels
    CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,nucleus
    text
  • membrane localization is dependent on its interacting protein, ACTN2, a major F-actin crosslinking protein
  • basic FUNCTION
  • voltage independant potassium channel which induces membrane hyperpolarization
  • functions of KCNN2 channels in atrial myocytes are critically dependent on the normal expression of CACNA1D
  • KCNN2 channels are necessary for long-term survival of olivocochlear fibers and synapses
  • important functional roles of KCNN2 channels in cardiac repolarization in atrial myocytes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS nervous system , facilitated diffusion transport
    PATHWAY
    metabolism
    signaling
    a component four channel subunits and four calmodulin subunits
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to CALM1
  • interacting with ACTN2 (its membrane localization is dependent on its interacting protein, ACTN2, a major F-actin crosslinking protein)
  • cell & other
    REGULATION
    activated by intracellular calcium Ca2+
    inhibited by apamin,scyllatoxin
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    enhances efferent suppression of cochlear responses without enhancing noise resistance
    Susceptibility
    Variant & Polymorphism
    Candidate gene for therapeutic modifying atrial cells without interfering with ventricular myocytes
    Marker
    Therapy target
    ANIMAL & CELL MODELS