Selected-GenAtlas references | SOURCE | GeneCards | NCBI Gene | Swiss-Prot | Ensembl |
HGNC | UniGene | Nucleotide | OMIM | UCSC |
Home Page |
FLASH GENE |
Symbol | KCNN2 | contributors: mct - updated : 09-01-2012 |
HGNC name | potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2 |
HGNC id | 6291 |
|
Location | 5q22.3 Physical location : 113.698.015 - 113.832.196 |
Synonym name | small conductance calcium-activated potassium channel protein 2 |
Synonym symbol(s) | SK2, HSK2, SKCA2, KCa2.2 |
DNA |
TYPE | functioning gene |
STRUCTURE | 134.18 kb 8 Exon(s) |
10 Kb 5' upstream gene genomic sequence study |
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MAPPING | cloned | Y | linked | N | status | provisional |
RNA |
TRANSCRIPTS | type | messenger |
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EXPRESSION |
Type |
expressed in | (based on citations) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
organ(s) |
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tissue |
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cells |
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cell lineage
cell lines
| fluid/secretion
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at STAGE |
physiological period | fetal |
Text | heart |
PROTEIN |
PHYSICAL PROPERTIES
STRUCTURE
| |
motifs/domains
| |
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conjugated | PhosphoP |
mono polymer | heteromer , oligo |
HOMOLOGY |
interspecies | ortholog to murine Kcnn2 |
homolog to Drosophila SK | |
homolog to C.elegans C03F11.1 |
Homologene |
FAMILY | KCNN family of potassium channels |
CATEGORY | transport channel |
SUBCELLULAR LOCALIZATION | plasma membrane |
intracellular | |
intracellular,nucleus | |
text |
basic FUNCTION | |
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CELLULAR PROCESS |
PHYSIOLOGICAL PROCESS | nervous system , facilitated diffusion transport |
PATHWAY |
metabolism |
signaling |
a component | four channel subunits and four calmodulin subunits |
INTERACTION |
DNA |
RNA |
small molecule |
protein | |
|
cell & other |
REGULATION |
activated by | intracellular calcium Ca2+ |
inhibited by | apamin,scyllatoxin |
ASSOCIATED DISORDERS |
corresponding disease(s) |
Other morbid association(s) |
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Susceptibility |
Variant & Polymorphism
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Candidate gene | for therapeutic modifying atrial cells without interfering with ventricular myocytes | |
Marker
Therapy target
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ANIMAL & CELL MODELS |