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FLASH GENE
Symbol KCNN1 contributors: mlc - updated : 26-10-2007
HGNC name potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1
HGNC id 6290
Location 19p13.1      Physical location : 18.062.110 - 18.109.929
Synonym name
  • small-conductance calcium-activated potassium channel
  • Synonym symbol(s) SK1, KCa2.1, SKCA1, hSK1
    DNA
    TYPE functioning gene
    STRUCTURE 47.00 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    Physical map
    PGLS 19p13.2 6-phosphogluconolactonase BCNP1 19p13.12 B-cell novel protein 1 FLJ22329 19p13.12 hypothetical protein FLJ22329 UNC13A 19p13.12 unc-13 homolog A (C. elegans) VCY2IP1 19p13.12 VCY2 interacting protein 1 KIAA0290 B3GNT3 19p13.1 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 INSL3 19p13.1-p12 insulin-like 3 (Leydig cell) JAK3 19p13.1 Janus kinase 3 (a protein tyrosine kinase, leukocyte) RPL18A 19p13 ribosomal protein L18a SLC5A5 19p13.2-p12 solute carrier family 5 (sodium iodide symporter), member 5 LOC115098 19p13.12 hypothetical protein BC013949 KCNN1 19p13.1 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1 CLONE24945 LOC284438 19p13.12 similar to Citrate synthase, mitochondrial precursor LOC126358 19p13.12 similar to apolipoprotein A-I binding protein; apoA-I binding protein LOC390897 19 similar to ribosomal protein S18 IL12RB1 19p13.1 interleukin 12 receptor, beta 1 KIAA0561 PIK3R2 19q13.2-q13.4 phosphoinositide-3-kinase, regulatory subunit, polypeptide 2 (p85 beta) IFI30 19p13.1 interferon, gamma-inducible protein 30 MGC12972 19p13.11 hypothetical protein MGC12972 RAB3A 19p13.1 RAB3A, member RAS oncogene family PDE4C 19P13.1 phosphodiesterase 4C, cAMP-specific (phosphodiesterase E1 dunce homolog, Drosophila) LOC388516 19 LOC388516 KIAA1683 19p13.1 KIAA1683 JUND 19p13.1 jun D proto-oncogene LSM4 19p13.1 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae) PGPEP1 19p13.11 pyroglutamyl-peptidase I PLAB MGC10812 19p13.11 hypothetical protein MGC10812 LOC388517 19 similar to MOST-1 protein
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 2657 - 543 - Wei (2005)
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivestomach    
    Nervousbrain    
    Visualeye    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    putative transmembrane domain and pore region
    HOMOLOGY
    Homologene
    FAMILY subfamily N
    CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • potassium intermediate/small conductance calcium-activated channel
  • regulating neuronal excitability
  • may be playing an important role in the pathophysiology of pain following nerve injury
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS