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FLASH GENE
Symbol KCNMB4 contributors: npt/ - updated : 09-05-2005
HGNC name potassium large conductance calcium-activated channel, subfamily M, beta member 4
HGNC id 6289
Location 12q14.1-q15      Physical location : 70.760.061 - 70.824.977
Synonym name
  • potassium non voltage gated,large conductance calcium activated channel, subfamily M, beta member 4
  • BK channel subunit beta-4
  • Synonym symbol(s) BKbeta4, K(VCA)beta-4, Slo-beta-4
    DNA
    TYPE functioning gene
    STRUCTURE 64.92 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    IL26 12q15 interleukin 26 IL22 12q15 interleukin 22 MDM1 12q14.3 nuclear protein double minute 1 LOC160410 12q14.3 proteasome (prosome, macropain) 26S subunit, ATPase, 6 pseudogene LOC387867 12 similar to 40S ribosomal protein SA (P40) (34/67 kDa laminin receptor) (Colon carcinoma laminin-binding protein) (NEM/1CHD4) (Multidrug resistance-associated protein MGr1-Ag) RAP1B 12q14 RAP1B, member of RAS oncogene family LOC246723 12q14 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit d pseudogene NUP107 12q14.3 nuclear pore complex protein SLC35E3 12q15 solute carrier family 35, member E2 PRO2268 12q14.3 hypothetical protein PRO2268 MDM2 12q14.3-q15 Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse) MGC5370 12q14.3 hypothetical protein MGC5370 CPM 12q15 carboxypeptidase M CPSF6 12q13.2 cleavage and polyadenylation specific factor 6, 68kDa LYZ 12q14-q15 lysozyme (renal amyloidosis) GAS41 12q13-q15 lysozyme (renal amyloidosis) FRS2 12q15 fibroblast growth factor receptor substrate 2 CCT2 12q15 chaperonin containing TCP1, subunit 2 (beta) LOC387868 12 similar to leucine-rich repeat-containing 10; leucine-rich repeat protein; leucine-rich containing 10 VMD2L3 12q14.2-q15 similar to leucine-rich repeat-containing 10; leucine-rich repeat protein; leucine-rich containing 10 MGC13168 12q14.3 hypothetical protein MGC13168 RAB3IP 12q13-q15 RAB3A interacting protein (rabin3) FLJ25056 12q14.3 hypothetical protein FLJ25056 CNOT2 12q13.2 CCR4-NOT transcription complex, subunit 2 KCNMB4 12q14.1-q15 potassium large conductance calcium-activated channel, subfamily M, beta member 4 LOC390342 12 similar to Gag-Pro-Pol-Env protein PTPRB 12q15 protein tyrosine phosphatase, receptor type, B PTPRR 12q13.2-q13.3 protein tyrosine phosphatase, receptor type, R TM4SF3 12q14.1-q21.1 transmembrane 4 superfamily member 3 GPR49 12q22-q23 G protein-coupled receptor 49 MGC23401 12q15 hypothetical protein MGC23401 DKFZP564I0422 12q15 hypothetical protein DKFZp564I0422 FLJ10936 12q15 hypothetical protein FLJ10936 RAB21 12q13.3 RAB21, member RAS oncogene family FLJ12085 TPH2 12q15 tryptophan hydroxylase 2 TRHDE 12q15-q21 Homo sapiens thyrotropin-releasing hormone degrading ectoenzyme (TRHDE), mRNA.
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 1631 23.82 210 - -
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   moderately
    Reproductivemale systemprostate  moderately
    Urinarykidney   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervouscentral   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two conserved transmembranes domains
  • an extracellular domain
  • an N glycosylation site
  • four cys residues
  • mono polymer aggregate
    HOMOLOGY
    interspecies ortholog to murine Kcnmb4
    homolog to rattus Kcnmb4
    Homologene
    FAMILY
  • KCNMB family
  • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • fundamentally involved in the control of smooth muscle tone and neuronal excitability
  • leading to steeper calcium sensitivity and shifts the voltage range of current activation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text calcium-activated potassium channel
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by calcium Ca2+
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS