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FLASH GENE
Symbol KCNMB2 contributors: - updated : 09-05-2005
HGNC name potassium large conductance calcium-activated channel, subfamily M, beta member 2
HGNC id 6286
Location 3q26.3-q27.1      Physical location : 178.254.223 - 178.562.216
Synonym name
  • MaxK channel beta 2 subunit
  • potassium non voltage gated,large conductance calcium activated channel, subfamily M, beta member
  • DNA
    TYPE functioning gene
    STRUCTURE 10.00 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence alternative promoter
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 2499 - 235 - Heartness
    - - 2543 - 235 - Heartness
    the longer transcript. Variants 1 and 2 encode the same protein
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine   
     pancreas exocrine    
    Reproductivefemale systemovary   
     male systemtestis   
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularsmooth   
    Muscularstriatumcardiac  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text kidney,lung
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a large N terminal extracellular loops
  • two transmembrane domains
  • three potential N glycosylation sites
  • four conserved cysteine residues
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Kcnmb2
    homolog to rattus Kcnmb2
    intraspecies homolog to KCNMB1
    Homologene
    FAMILY
  • KCNMB family, subfamily M, beta member
  • MaxiK
  • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    text integral to membrane
    basic FUNCTION
  • regulator (inactivator) of calcium activated channel, fundamental in the control of muscle tone and neuronal excitability
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • complexing with (and inactivator of) KCNMA1
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS