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FLASH GENE
Symbol KCNMB2 contributors: - updated : 09-05-2005
HGNC name potassium large conductance calcium-activated channel, subfamily M, beta member 2
HGNC id 6286
Location 3q26.3-q27.1      Physical location : 178.254.223 - 178.562.216
Synonym name
  • MaxK channel beta 2 subunit
  • potassium non voltage gated,large conductance calcium activated channel, subfamily M, beta member
  • DNA
    TYPE functioning gene
    STRUCTURE 10.00 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence alternative promoter
    MAPPING cloned Y linked N status provisional
    Physical map
    IRA1 3q26.33 likely ortholog of mouse IRA1 protein LOC339845 3q26.33 similar to argininosuccinate synthetase KCNMB2 3q26.3-q27.1 potassium large conductance calcium-activated channel, subfamily M, beta member 2 WIG1 3q26.3-q27 potassium large conductance calcium-activated channel, subfamily M, beta member 2 PIK3CA 3q26.3 phosphoinositide-3-kinase, catalytic, alpha polypeptide KCNMB3 3q26.3-q27.1 potassium large conductance calcium-activated channel, subfamily M beta member 3 ANC_2H01 3q27.1 zinc finger protein ANC_2H01 MFN1 3q27.1 mitofusin 1 GNB4 21q22.3 guanine nucleotide binding protein (G protein), beta polypeptide 4 BAF53A 3q27.1 guanine nucleotide binding protein (G protein), beta polypeptide 4 MRPL47 3q27.1 mitochondrial ribosomal protein L47 NDUFB5 3q27.1 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa USP13 3q26.2-q26.3 ubiquitin specific protease 13 (isopeptidase T-3) PEX5R 3q27.1 Pex5p-related protein LOC391593 3 similar to Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) (38 kDa BFA-dependent ADP-ribosylation substrate) (BARS-38) LOC131054 3q27.2 similar to RalA binding protein 1 (RalBP1) (Ral interacting protein 1) (76-kDa Ral-interacting protein) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase) TTC14 3q27.2 tetratricopeptide repeat domain 14 DKFZp434A128 3q27.2 hypothetical protein DKFZp434A128 LOC389178 3 similar to RING finger protein 13 LOC391594 3 similar to KIAA1552 protein LOC391595 3 similar to 60S ribosomal protein L32 FXR1 3q28 fragile X mental retardation, autosomal homolog 1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 2499 - 235 - Heartness
    - - 2543 - 235 - Heartness
    the longer transcript. Variants 1 and 2 encode the same protein
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine   
     pancreas exocrine    
    Reproductivefemale systemovary   
     male systemtestis   
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularsmooth   
    Muscularstriatumcardiac  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text kidney,lung
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a large N terminal extracellular loops
  • two transmembrane domains
  • three potential N glycosylation sites
  • four conserved cysteine residues
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Kcnmb2
    homolog to rattus Kcnmb2
    intraspecies homolog to KCNMB1
    Homologene
    FAMILY
  • KCNMB family, subfamily M, beta member
  • MaxiK
  • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    text integral to membrane
    basic FUNCTION
  • regulator (inactivator) of calcium activated channel, fundamental in the control of muscle tone and neuronal excitability
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • complexing with (and inactivator of) KCNMA1
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS