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FLASH GENE

Symbol

KCNK7

contributors: - updated : 03-10-2007

HGNC name	potassium channel, subfamily K, member 7
HGNC id	6282

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	11q13      Physical location : 65.360.326 - 65.363.467
Synonym name	weakly inward rectifying K+ channel 3
	TWIK-1-like channel
Synonym symbol(s)	TWIK3, K2p7.1, MGC118782, MGC118784

DNA

TYPE	anonymous DNA segment
STRUCTURE	3.00 kb     3 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed KCNK7A - - 1312 - 307 - Salinas, Goldstein KCNK7B - splicing 1388 - 252 - Salinas, Goldstein truncated KCNK7C - - 1577 - 257 - Salinas, Goldstein truncated KCNK7D - - 1485 - 252 - Goldstein

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Nervous brain       predominantly Reproductive female system placenta       Respiratory lung         Visual eye

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	four transmembrane domains
	two pore forming regions with two P domains arranged like a tandem of inward rectifier channels

mono polymer

homomer , dimer

HOMOLOGY

Homologene

FAMILY

potassium channel, subfamily K

CATEGORY

transport channel

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION

may require other non-pore-forming proteins for activity

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS