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FLASH GENE
Symbol KCNK6 contributors: - updated : 07-09-2005
HGNC name potassium channel, subfamily K, member 6
HGNC id 6281
Location 19q13.1      Physical location : 38.810.483 - 38.819.643
Synonym name TWIK-originated sodium similarity sequence
Synonym symbol(s) TWIK2, FLJ12282, KCNK8, TOSS,
DNA
TYPE functioning gene
STRUCTURE 9.00 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Map cen - D19S228 - KCNK6 - D19S220 - qter
Authors Gray (99)
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivestomach    
Hearing/Equilibriumearinnercochlea  
Respiratorylung    
Visualeye    
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo, pregnancy
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four transmembrane segments
  • two pore forming regions
  • two P-domains arranged like a tandem of inward rectifier channels
  • HOMOLOGY
    Homologene
    FAMILY potassium channel, subfamily K
    CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    basic FUNCTION
  • tandem pore domain potassium channel playing a potential role as one of the terminal components of the potassium ion-recycling pathway contributing toward its reabsorption into the endolymph
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS