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FLASH GENE
Symbol KCNK4 contributors: npt/ - updated : 07-10-2004
HGNC name potassium channel, subfamily K, member 4
HGNC id 6279
Location 11q13      Physical location : 64.058.792 - 64.067.502
Synonym name
  • polyunsatured fatty acids-activated and mechanosensitive K+ channel
  • potassium non voltage gated channel
  • TWIK-related arachidonic acid-stimulated potassium channel protein
  • K2P4.1 potassium channel
    • Synonym symbol(s) TRAAK, CIW4, K2p4.1, TRAAK1
    DNA
    TYPE functioning gene
    STRUCTURE 8.71 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC283248 11q13.1 hypothetical protein LOC283248 FLJ13848 11q13.1 hypothetical protein FLJ13848 COX8 11q13.1 cytochrome c oxidase subunit VIII OTUB1 11q13.1 OTU domain, ubiquitin aldehyde binding 1 LRP16 11q11 LRP16 protein LOC387776 11 LOC387776 FLRT1 11q12-q13 fibronectin leucine rich transmembrane protein 1 STIP1 11q13.2 stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing protein) URP2 11q13.1 UNC-112 related protein 2 short form MGC11134 11q13.1 tRNA splicing 2' phosphotransferase 1 MGC13045 11q13.1 hypothetical protein MGC13045 DNAJC4 11q13 DnaJ (Hsp40) homolog, subfamily C, member 4 VEGFB 11q13 vascular endothelial growth factor B FKBP2 11q13.1 FK506 binding protein 2, 13kDa PPP1R14B 11q13 protein phosphatase 1, regulatory (inhibitor) subunit 14B PLCB3 11q13.1-q13.2 phospholipase C, beta 3 (phosphatidylinositol-specific) BAD 11q12.3 BCL2-antagonist of cell death C11ORF4 11cen-q22.3 chromosome 11 hypothetical protein ORF4 KCNK4 11q13 potassium channel, subfamily K, member 4 ESRRA 11q12-q13 estrogen-related receptor alpha HSPC152 11q13.1 hypothetical protein HSPC152 PRDX5 11q13.1 peroxiredoxin 5 FLJ37970 11q12.3 hypothetical protein FLJ37970 RPS6KA4 11q11-q13 ribosomal protein S6 kinase, 90kDa, polypeptide 4 LOC387777 11 LOC387777 FLJ37045 11q13.1 hypothetical protein FLJ37045 SLC22A11 11q13.1 solute carrier family 22 (organic anion/cation transporter), member 11 SLC22A12 11q13.1 solute carrier family 22 (organic anion/cation transporter), member 12 NRXN2 11q13.2 neurexin 2
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - splicing 2733 - 419 - Lesage,Ozaita
    11 exons
    - splicing 1696 42.7 393 - Lesage,Ozaita
    7 exons
    - splicing 1821 42.7 393 - Lesaga
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveliver    
    Endocrinepancreas    
    Nervousbrainhindbraincerebellum  
     spinal cord    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelial    
    Muscularstriatumskeletal  
    Nervouscentral   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo, pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • four transmembrane segments
  • two pore forming regions (P domains)
  • two P domains arranged like a tandem of inward rectifier channels
    • HOMOLOGY
    intraspecies homolog to TASK1
    Homologene
    FAMILY
  • two pore domain family of potassium channel family
    • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION unknown
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling neurotransmission
    synaptic transmission
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by arachidonic acid,unsatured fatty acid,neuroprotective drug riluzole
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS