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FLASH GENE
Symbol KCNK4 contributors: mct - updated : 22-10-2014
HGNC name potassium channel, subfamily K, member 4
HGNC id 6279
Location 11q13      Physical location : 64.058.792 - 64.067.502
Synonym name
  • polyunsatured fatty acids-activated and mechanosensitive K+ channel
  • potassium non voltage gated channel
  • TWIK-related arachidonic acid-stimulated potassium channel protein
  • K2P4.1 potassium channel
    • Synonym symbol(s) TRAAK, CIW4, K2p4.1, TRAAK1
    DNA
    TYPE functioning gene
    STRUCTURE 8.71 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - splicing 2733 - 419 - Lesage,Ozaita
    11 exons
    - splicing 1696 42.7 393 - Lesage,Ozaita
    7 exons
    - splicing 1821 42.7 393 - Lesaga
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveliver    
    Endocrinepancreas    
    Nervousbrainhindbraincerebellum  
     spinal cord    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelial    
    Muscularstriatumskeletal  
    Nervouscentral   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo, pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • four transmembrane segments
  • two pore forming regions (P domains)
  • two P domains arranged like a tandem of inward rectifier channels
    • HOMOLOGY
    intraspecies homolog to TASK1
    Homologene
    FAMILY
  • two pore domain family of potassium channel family
    • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION unknown
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling neurotransmission
    synaptic transmission
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • KCNK2, KCNK4, KCNK10 interact with partner proteins that influence their activity and their plasma membrane expression
    • cell & other
    REGULATION
    activated by arachidonic acid,unsatured fatty acid,neuroprotective drug riluzole
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS