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FLASH GENE
Symbol KCNK2 contributors: mct/npt - updated : 22-10-2014
HGNC name potassium channel, subfamily K, member 2
HGNC id 6277
Location 1q41      Physical location : 215.178.884 - 215.410.435
Synonym name
  • TWIK-related potassium channel 1
  • tandem-pore-domain potassium channel TREK-1 splice variant e
  • two pore potassium channel TPKC1
  • K2P2.1 potassium channel
  • Synonym symbol(s) TREK1, MGC126742, MGC126744, TPKC1, TREK, TREK-1, hTREK-1c, hTREK-1e, K2p2.1
    DNA
    TYPE functioning gene
    STRUCTURE 231.55 kb     7 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 3597 - 422 - 2010 20605797
    7 - 3274 - 411 - 2010 20605797
    7 - 3398 - 426 - 2010 20605797
    6 - 2496 - 370 . in the brain . retained in the intracellular compartment 2010 20605797
  • truncated protein, retaining a single transmembrane domain
  • has no channel activity itself but reduced KCNK2 whole cell current amplitude
  • might have some dominant-negative effect on KCNK2 expression
  • EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivesalivary gland   highly
    Endocrinepancreas   highly
     thyroid   highly
    Nervousbrain   highly Homo sapiens
    Reproductivefemale systemuterus    Homo sapiens
     female systemovary  highly Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularsmoothmyoepithelium highly Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousastrocyte Homo sapiens
    Nervousneuron
    Skeletonosteoblast
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal domain and first transmembrane domain are likely to be important for channel dimerization and trafficking to the plasma membrane
  • four transmembrane segments
  • two pore forming regions (P domains) with two P-domains arranged like a tandem of outward rectifier channels
  • mono polymer homomer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • two pore domain potassium channel (TC 1.A.1.8) family
  • potassium channel, subfamily K
  • two-pore domain (K2P)5 K+ channel family
  • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text localized at the plasma membrane and cytoplasm close to the plasma membrane when coexpressed with each splice variant
    basic FUNCTION
  • potassium non voltage-gated heat activated background channel outwardly rectifying, candidate physiological thermoreceptor
  • playing a possible role in mechanotransduction, leading to bone remodelling
  • having a role in adrenal glomerulosa cells for their background potassium current (Brenner 2008)
  • KCNK2, KCNK10 are potently activated by polyunsaturated fatty acids and are involved in neuroprotection, anesthesia, and pain perception
  • role in contributing to uterine quiescence during gestation and hypothesize that dysregulation of this mechanism may underlie certain cases of spontaneous pre-term birth
  • may participate in pathophysiologic alteration and electrical remodelling of left ventricular myocardium after MI, which may eventually lead to post-MI ventricular arrhythmias
  • could be involved in regulation of alveolar epithelial cell proliferation and cytokine secretion
  • may be important to protect disc cells against ischaemic damage, and subsequent disc degeneration, and may also play a role in effecting mechanotransduction
  • KCNK2 activity is involved in astrocytic function and neuronal survival
  • KCNK2 and BEST1 mediate fast and slow glutamate release in acutely dissociated astrocytes
  • eukaryotic mechanosensitive channel, directly sensitive to a modification of membrane tension
  • endothelial KCNK2 regulates immune-cell trafficking into the CNS
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • formed by two homodimers that create a channel that leaks potassium out of the cell to control resting membrane potential
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • protein-protein interaction between KCNK2 and COPB2 (
  • KCNK2, KCNK4, KCNK10 interact with partner proteins that influence their activity and their plasma membrane expression
  • C terminus of GNG4 showed strong interaction with KCNK2, whereas N terminus did not
  • cell & other
    REGULATION
    activated by volatile general anaesthetics such as chloroform, halothane and isoflurane
    by fenamates
    inhibited by external acidification
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       loss of function
    KCNK2 deficient cells have less F-actin and are more deformable making them more resistant to stretch-induced injury
    constitutional     --over  
    in human endometrium with molecular expression of KCNK2 shown to be higher in proliferative than secretory phase endometrium
    constitutional     --over  
    during gestation to term such that it may maintain uterine quiescence by hyperpolarizing the smooth muscle cell membrane
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS