Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol KCNK18 contributors: mct - updated : 16-03-2011
HGNC name potassium channel, subfamily K, member 18
HGNC id 19439
Location 10q26.11      Physical location : 118.956.999 - 118.969.809
Synonym name
  • TWIK-related spinal cord K+ channel 2
  • TWIK-related spinal cord potassium channel
  • Synonym symbol(s) TRESK, TRESK-2, TRESK2, TRIK, K2p18.1, MGR13
    DNA
    TYPE functioning gene
    STRUCTURE 12.81 kb     3 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 1255 - 384 - 2003 12754259
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunespleen   highly Homo sapiens
     thymus   highly Homo sapiens
    Nervousbrain     Homo sapiens
     spinal cord   highly Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymphocyte Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two pore-forming domains
  • four transmembrane domains
  • an NFAT-like docking site that is present at its intracellular loop
  • HOMOLOGY
    interspecies homolog to murine Kcnk18
    homolog to C. elegans twk-6
    Homologene
    FAMILY double-pore domain K+ channel family
    CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    text integral to membrane
    basic FUNCTION
  • acting as a potassium channel
  • may set the resting membrane potential of cells in the spinal cord
  • key role in controlling neuronal resting membrane potential and neuronal excitability
  • target of volatile anesthetics and potential role in mediating the effects of inhaled anesthetics in the central nervous system
  • activation of both KCNK18 and NFAT via Ca(2+)-calcineurin-NFAT/KCNK18 pathway could modulate the transcription of new genes in addition to regulating several aspects of T-cell function
  • role in the pathogenesis of typical migraine with aura
  • plays an key part in the excitability of neurons that are crucial to migraine pathogenesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text
  • potassium ion transport
  • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • calcineurin has been found to interact with KCNK18 via specific NFAT-like docking site
  • cell & other
    REGULATION
    activated by reversibly activated by the calcium/calmodulin-dependent protein phosphatase, calcineurin
    by volatile anesthetics such as halothane
    highly activated by Ca(2+), calcineurin, acetylcholine, and histamine which induce hypertrophy
    inhibited by immunosuppressants, such as cyclosporin A and FK506
    Other regulated by the calcium/calmodulin-dependent phosphatase calcineurin and 14-3-3 adaptor proteins
    phosphorylation of KCNK18 at two distinct regulatory regions, the 14-3-3 binding site (Ser-264) and the cluster of three adjacent serine residues (Ser-274, Ser-276, and Ser-279), are responsible for channel inhibition
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    neurologyepilepsy 
    potential therapeutic target in familial migraine with aura
    ANIMAL & CELL MODELS