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FLASH GENE
Symbol KCNK17 contributors: mct/npt - updated : 03-03-2009
HGNC name potassium channel, subfamily K, member 17
HGNC id 14465
Location 6p21.2      Physical location : 39.266.777 - 39.282.237
Synonym name
  • potassium channel TALK-2
  • potassium channel TASK-4
  • 2P domain potassium channel Talk-2
  • TWIK-related alkaline pH-activated K(+) channel 2
    • Synonym symbol(s) TALK2, TASK4, TALK-2, TASK-4, K2p17.1
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 15.50 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 1589 36.9 332 - -
    - - 1741 - 271 - Mungall (2003)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivepancreas exocrine   specific
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two pore-forming P domain
    • HOMOLOGY
    Homologene
    FAMILY
  • two pore domain potassium channel family
  • 2P domain potassium channel (K(2P)) family
    • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • might regulate cellular membrane potential
  • two-pore region (2P) KCNK K+ channel gated open by extracellular alkalinization (Niemeyer 2007)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text ion transport protein
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by alkaline PH
    strongly and specifically activated by nitric oxide superoxide anion and singlet oxygen (Duprat 2005)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS