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FLASH GENE
Symbol KCNK16 contributors: mct/npt - updated : 03-03-2009
HGNC name potassium channel, subfamily K, member 16
HGNC id 14464
Location 6p21.2      Physical location : 39.282.474 - 39.290.330
Synonym name
  • pancreatic 2P domain potassium channel TALK-1
  • TWIK-related alkaline pH-activated K(+) channel 1
  • Synonym symbol(s) TALK-1, TALK1, K2p16.1, MGC133123
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 7.83 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map pter - D6S9463 - D6S2106 - KCNK16 - D6S1680 - D6S1610 - cen
    Physical map
    RNF8 6p21.3 ring finger protein (C3HC4 type) 8 KIAA0082 6p21.2 ring finger protein (C3HC4 type) 8 C6orf129 6p21.2 chromosome 6 open reading frame 129 MDGA1 6p21 MAM domain containing glycosylphosphatidylinositol anchor 1 TEX27 6pter-p22.3 testis expressed sequence 27 BTBD9 6p21 BTB (POZ) domain containing 9 GLO1 6p21.1 glyoxalase I DNAH8 6p21 dynein, axonemal, heavy polypeptide 8 GLP1R 6p21 glucagon-like peptide 1 receptor C6orf64 6p21.2 chromosome 6 open reading frame 64 KCNK5 6p21 potassium channel, subfamily K, member 5 KCNK17 6p21.2-p21.1 potassium channel, subfamily K, member 17 KCNK16 6p21.2-p21.1 potassium channel, subfamily K, member 16 C6orf102 6p21.2 chromosome 6 open reading frame 102 DAAM2 6p21.1 dishevelled associated activator of morphogenesis 2 MOCS1 6p21.3-p21.1 molybdenum cofactor synthesis 1 LOC391918 6 similar to ribosomal protein L23 LOC391919 6 similar to tubulin, beta 5 LOC389388 6 LOC389388 KIAA1246 6p21.1 LOC389388 UNC5CL 6p21.1 unc-5 homolog C (C. elegans)-like BZRPL1 6p21.1 benzodiazapine receptor (peripheral)-like 1 APOBEC2 6p21 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2 C6orf130 6p21.1 chromosome 6 open reading frame 130 NFYA 6p21.3 nuclear transcription factor Y, alpha LOC221442 6p21.1 hypothetical protein LOC221442 TREML1 6p21.1 triggering receptor expressed on myeloid cells-like 1 TREM2 6p21.1 triggering receptor expressed on myeloid cells 2 C6orf76 6p21.1 chromosome 6 open reading frame 76 LOC285852 6p21.1 hypothetical protein LOC285852
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 1226 34.15 309 - Han (2003)
    four transmembrane segments (Han 2003)
    5 - 1412 - 322 - Mungall (2003)
  • lacked the fourth transmembrane domain because of deletion of exon 5 (Han 2003)
  • - - 947 - 294 - Mungall (2003)
  • four transmembrane segments (Han 2003)
  • sensitive to changes in external pH (Han 2003)
  • 5 - 1110 - 262 - Mungall (2003)
  • lacked the fourth transmembrane domain because of deletion of exon 5 (Han 2003)
  • EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivepancreas exocrine   specific
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two pore-forming P domains
  • four transmembrane segments
  • HOMOLOGY
    Homologene
    FAMILY
  • tandem-pore K+ channel family
  • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • two-pore region (2P) KCNK K+ channel gated open by extracellular alkalinization (Niemeyer 2007)
  • may serve as background K+ currents in certain cells of the pancreas (Han 2003)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by alkaline PH
    strongly and specifically activated by nitric oxide superoxide anion and singlet oxygen (Duprat 2005)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS