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FLASH GENE
Symbol KCNK13 contributors: mct/npt - updated : 02-03-2009
HGNC name potassium channel, subfamily K, member 13
HGNC id 6275
Location 14q32.11      Physical location : 90.528.107 - 90.652.195
Synonym name
  • tandem pore domain halothane inhibited K+ channel 1
  • tandem pore domain potassium channel THIK-1
  • Synonym symbol(s) THIK-1, K2p13.1, THIK1
    DNA
    TYPE functioning gene
    STRUCTURE 124.00 kb     2 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    GPR65 14q31.1 G protein-coupled receptor 65 LOC283587 14q31.3 hypothetical protein LOC283587 KCNK10 14q31 potassium channel, subfamily K, member 10 SPATA7 14q31.3 spermatogenesis associated 7 PTPN21 14q31.1 protein tyrosine phosphatase, non-receptor type 21 FLJ11806 14q31.3 nuclear protein UKp68 EML5 14q31.3 echinoderm microtubule associated protein like 5 TTC8 14q31.3 tetratricopeptide repeat domain 8 LOC390501 14 similar to MPPE1 protein CHES1 14q24.3-q31 checkpoint suppressor 1 C14orf116 14q31.3 chromosome 14 open reading frame 116 CAP2P1 14 CAP, adenylate cyclase-associated protein, 2 (yeast) pseudogene 1 PRO1768 14q32.11 PRO1768 protein CHORDC2P 14 cysteine and histidine-rich domain (CHORD)-containing 2 pseudogene C14orf143 14q32.11 chromosome 14 open reading frame 143 TDP1 14q32.11 tyrosyl-DNA phosphodiesterase 1 KCNK13 14q24.1-q24.3 potassium channel, subfamily K, member 13 GLRXP2 14q32.13-q32.2 glutaredoxin pseudogene 2 PSMC1 19p13.3 proteasome (prosome, macropain) 26S subunit, ATPase, 1 C14orf102 14q32.11 chromosome 14 open reading frame 102 RPL21P11 14q32.11 ribosomal protein L21 pseudogene 11 CALM1 14q24-q31 calmodulin 1 (phosphorylase kinase, delta) TTC7L1 14q32.12 tetratricopeptide repeat domain 7 like 1 RPS18P2 14 ribosomal protein S18 pseudogene 2 LOC283588 14q32.12 hypothetical protein LOC283588 RPS6KA5 14q31-q32.1 ribosomal protein S6 kinase, 90kDa, polypeptide 5 C14orf159 14q32.12 chromosome 14 open reading frame 159 GPR68 14q31 G protein-coupled receptor 68 KIAA1509 14q32.12 KIAA1509 LOC388005 14 similar to RIKEN cDNA 0610010D24 KIAA2010 14q32.12 KIAA2010 C14orf161 14q32.12 chromosome 14 open reading frame 161 MTAC2D1 14q32.12 membrane targeting (tandem) C2 domain containing 1 FBLN5 14q32.1 fibulin 5 TRIP11 14q31-q32 thyroid hormone receptor interactor 11 PTMAP7 14 prothymosin, alpha pseudogene 7 MJD 14q24.4-q32.1 Machado-Joseph disease (spinocerebellar ataxia 3, olivopontocerebellar ataxia 3, autosomal dominant, ataxin 3)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 2517 45.4 408 - Theilig (2008)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Urinarykidneytubulecollecting duct   Homo sapiens
     kidneytubuleconvoluted tubuleproximal tubule  Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    intraspecies homolog to KCNK12 (60 p100)
    Homologene
    FAMILY
  • KCNK family
  • two pore domain potassium channel family
  • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • may be involved in both the maintenance of neuronal phenotype and in the specific functional role of these neurons in their respective networks (Jezzini 2004)
  • KCNK12, KCNK13 form active heteromeric channels, further expanding the known repertoire of K(+) channels
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text potassium channel
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS