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FLASH GENE
Symbol KCNK12 contributors: mct/npt - updated : 25-11-2015
HGNC name potassium channel, subfamily K, member 12
HGNC id 6274
Location 2p16.3      Physical location : 47.747.916 - 47.797.470
Synonym name tandem pore domain halothane inhibited K+ channel 2
Synonym symbol(s) THIK2,THIK-2
DNA
TYPE functioning gene
STRUCTURE 53.76 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 1449 46.9 430 - 2008 18209473
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinepancreas    
Nervousbrain    
Urinarykidneytubulecollecting duct   Homo sapiens
 kidneytubuleconvoluted tubule   Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • highly conserved 19AA region in its N terminus (AAs 6-24 in the rat orthologue) that is missing in the closely related channel KCNK13
  • cytoplasmic N-terminal region (Nt-THIK2) contains an arginine-rich motif (RRSRRR) that acts as a retention/retrieval signal
    • HOMOLOGY
    intraspecies homolog to KCNK13 (60 p100)
    Homologene
    FAMILY
  • two pore domain potassium channel family
  • potassium channel subfamily K (KCNK family)
    • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text mainly localised to the endoplasmic reticulum
    basic FUNCTION
  • may be involved in both the maintenance of neuronal phenotype and in the specific functional role of these neurons in their respective networks (Jezzini 2004)
  • KCNK12, KCNK13 form active heteromeric channels, further expanding the known repertoire of K(+) channels
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text
  • ion transport
  • potassium channel
    • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other phosphorylation-dependent regulation of KCNK12 trafficking
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS