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FLASH GENE

Symbol

KCNK10

contributors: mct - updated : 22-10-2014

HGNC name	potassium channel, subfamily K, member 10
HGNC id	6273

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	14q31.3      Physical location : 88.646.453 - 88.793.256
Synonym symbol(s)	TREK2, K2P10.1

DNA

TYPE	functioning gene
STRUCTURE	146.80 kb     7 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_021161 7 splicing 7518 NP_066984 59 538 - 2011 21669980 the longest transcript but encoding the shortest protein NM_138317 7 splicing 7527 NP_612190 60 543 . kidney (proximal tube) highly, pancreas higly 2011 21669980 having a different first exon than variant 1 resulting in a different N terminus longer by 5 AA than the isoform 1 NM_138318 7 splicing 7198 NP_612191 60 543 brain highly 2011 21669980

EXPRESSION

Type

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine colon   lowly   intestine small intestine       Endocrine pancreas       highly Nervous brain forebrain cerebral lobe occipital   nervous brain basal nuclei putamen     Nervous brain diencephalon thalamus     Reproductive female system ovary       Homo sapiens Urinary kidney       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine   Lymphoid

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	four transmembrane segments
	two pore-forming domains arranged in a tandem outward rectifier channel

conjugated

GlycoP

HOMOLOGY

interspecies	Drosophilia Ir
	homolog to C.elegans irk-2

intraspecies

homolog to TREK1

Homologene

FAMILY	two-pore domain (K2P) superfamily
	potassium channel, subfamily K

CATEGORY

transport channel

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	target of neurotransmitter action
	exhibits two primary modes of gating that give rise to two channel phenotypes under dephosphorylated conditions, and its phosphorylation shifts the gating mode to include intermediate conducting levels
	KCNK2, KCNK10 are potently activated by polyunsaturated fatty acids and are involved in neuroprotection, anesthesia, and pain perception

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

text	potassium channel
	passive transporter

PATHWAY

metabolism

signaling

neurotransmission , signal transduction

a component

INTERACTION

DNA

RNA

small molecule	other,
	zinc activated

protein	neurotransmitter receptors
	KCNK2, KCNK4, KCNK10 interact with partner proteins that influence their activity and their plasma membrane expression
	hyperpolarizes IB4 binding C-nociceptors and limits pathological spontaneous pain

cell & other

REGULATION

activated by	polyinsaturated fatty acids lysophospholipids,anesthetic chloroform,halothane,riluzole
	Gs,Gi,Gy protein coupled receptors
	arachidonic acid,membrane stretching,intracellular acidification

Other

mechadosensitive channel

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS