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FLASH GENE
Symbol KCNK10 contributors: mct - updated : 22-10-2014
HGNC name potassium channel, subfamily K, member 10
HGNC id 6273
Location 14q31.3      Physical location : 88.646.453 - 88.793.256
Synonym symbol(s) TREK2, K2P10.1
DNA
TYPE functioning gene
STRUCTURE 146.80 kb     7 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 splicing 7518 59 538 - 2011 21669980
the longest transcript but encoding the shortest protein
7 splicing 7527 60 543 . kidney (proximal tube) highly, pancreas higly 2011 21669980
  • having a different first exon than variant 1 resulting in a different N terminus longer by 5 AA than the isoform 1
  • 7 splicing 7198 60 543 brain highly 2011 21669980
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon lowly
     intestinesmall intestine   
    Endocrinepancreas   highly
    Nervousbrainforebraincerebral lobeoccipital 
    nervousbrainbasal nucleiputamen  
    Nervousbraindiencephalonthalamus  
    Reproductivefemale systemovary    Homo sapiens
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Lymphoid    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • four transmembrane segments
  • two pore-forming domains arranged in a tandem outward rectifier channel
  • conjugated GlycoP
    HOMOLOGY
    interspecies Drosophilia Ir
    homolog to C.elegans irk-2
    intraspecies homolog to TREK1
    Homologene
    FAMILY
  • two-pore domain (K2P) superfamily
  • potassium channel, subfamily K
  • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • target of neurotransmitter action
  • exhibits two primary modes of gating that give rise to two channel phenotypes under dephosphorylated conditions, and its phosphorylation shifts the gating mode to include intermediate conducting levels
  • KCNK2, KCNK10 are potently activated by polyunsaturated fatty acids and are involved in neuroprotection, anesthesia, and pain perception
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text
  • potassium channel
  • passive transporter
  • PATHWAY
    metabolism
    signaling neurotransmission , signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule other,
    zinc activated
    protein
  • neurotransmitter receptors
  • KCNK2, KCNK4, KCNK10 interact with partner proteins that influence their activity and their plasma membrane expression
  • hyperpolarizes IB4 binding C-nociceptors and limits pathological spontaneous pain
  • cell & other
    REGULATION
    activated by polyinsaturated fatty acids lysophospholipids,anesthetic chloroform,halothane,riluzole
    Gs,Gi,Gy protein coupled receptors
    arachidonic acid,membrane stretching,intracellular acidification
    Other mechadosensitive channel
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS