Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol KCNJ9 contributors: mct - updated : 12-05-2009
HGNC name potassium inwardly-rectifying channel, subfamily J, member 9
HGNC id 6270
Location 1q23.2      Physical location : 160.051.359 - 160.059.212
Synonym name
  • G protein coupled inward rectifier potassium channel
  • inwardly rectifier K(+) channel Kir3.3
  • Synonym symbol(s) GIRK3, KCNJ7, KIR3.3
    DNA
    TYPE functioning gene
    SPECIAL FEATURE arranged in tandem
    text arranged in tandem with KCNJ10
    STRUCTURE 7.85 kb     3 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC391118 1 similar to olfactory receptor MOR267-3 LOC391119 1 similar to olfactory receptor GA_x6K02T2R7CC-664297-665229 LOC343409 1q23.1 similar to Olfactory receptor 10J1 (Olfactory receptor-like protein HGMP07J) LOC391120 1 similar to olfactory receptor MOR267-3 LOC391121 1 similar to olfactory receptor MOR267-3 OR10J1 1q22 olfactory receptor, family 10, subfamily J, member 1 LOC127385 1q23.1 similar to Olfactory receptor 10J5 LOC391122 1 similar to porcine serum amyloid P component (SAP) APCS 1q23.2 amyloid P component, serum LOC339511 1q23.1 similar to Olfactory receptor 10J6 LOC171422 1q23.1 C-reactive protein pseudogene CRP 1q23.2 C-reactive protein, pentraxin-related FLJ20442 1q23.1 hypothetical protein FLJ20442 LOC343413 1q23.1 similar to Fc receptor homolog expressed in B cells; Fc receptor related protein X SLAMF8 1q23.1 SLAM family member 8 LOC391123 1 similar to hypothetical protein A030011M19 NESG1 1q22 similar to hypothetical protein A030011M19 TAGLN2 1q22 transgelin 2 IGSF9 1q22-q23 immunoglobulin superfamily, member 9 SLAMF9 1q23.1 SLAM family member 9 LOC391124 1 similar to ribosomal protein L27a; ribosomal protein L29 homolog (yeast) PIGM 1q22 phosphatidylinositol glycan, class M KCNJ10 1q22 potassium inwardly-rectifying channel, subfamily J, member 10 KCNJ9 1q22 potassium inwardly-rectifying channel, subfamily J, member 9 IGSF8 1q23.1 immunoglobulin superfamily, member 8 ATP1A2 1q22 ATPase, Na+/K+ transporting, alpha 2 (+) polypeptide ATP1A4 1q22 ATPase, Na+/K+ transporting, alpha 4 polypeptide CASQ1 1q22 calsequestrin 1 (fast-twitch, skeletal muscle) PEA15 1q22 phosphoprotein enriched in astrocytes 15 H326 1q22-q23 H326 LOC388707 1 hypothetical gene supported by BC005391; NM_002295 COPA 1q22 coatomer protein complex, subunit alpha PXF 1q22 peroxisomal farnesylated protein NCSTN 1q22 peroxisomal farnesylated protein NHLH1 1q22 nescient helix loop helix 1 VANGL2 1q22 vang-like 2 (van gogh, Drosophila) SLAMF6 1q23.1 SLAM family member 6 CD84 1q22-q23 CD84 antigen (leukocyte antigen) SLAMF1 1q21.3-1q23.2 signaling lymphocytic activation molecule family member 1 CD48 1q23 CD48 antigen (B-cell membrane protein)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 3029 43.9 393 - 2000 10913335
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus     Homo sapiens
    Nervousbrain    
    Reproductivemale systemtestis  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularsmoothmuscularis mucosa (tractus digestif)   Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two membrane-spanning domains
  • an amphipatic region pore, including the P domain with the K+ channel signature
  • an ATP-binding regulatory domain
  • a C-terminal intracellular domain with binding sites for NTRK2 and NCAM1
  • mono polymer homomer , tetramer
    HOMOLOGY
    Homologene
    FAMILY
  • inward rectifier-type potassium channel family
  • subfamily J
  • CATEGORY receptor , transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • G protein coupled, potassium non voltage-gated channel, inwardly rectifying
  • having a critical role for depotentiation, one form of excitatory synaptic plasticity
  • having a decisive role in regulating NCAM1-dependent neurite outgrowth
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • associates with another G-protein-activated potassium channel (GIRK1) to form a heteromultimeric pore-forming complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • directly binds to the neural cell adhesion molecule (NCAM1) and KCNJ9
  • cell & other
    REGULATION
    Other regulated by NTRK2 (regulates the cell surface expression of KCNJ9)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS