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FLASH GENE
Symbol KCNJ8 contributors: - updated : 24-05-2006
HGNC name potassium inwardly-rectifying channel, subfamily J, member 8
HGNC id 6269
Location 12p11.23      Physical location : 21.917.889 - 21.927.747
Synonym name ATP-sensitive inward rectifier potassium channel 8
Synonym symbol(s) KATP1, KIR6.1
DNA
TYPE functioning gene
STRUCTURE 9.00 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Lymphoid/Immunespleen    
Nervousbraindiencephalonhypothalamus  
Reproductivefemale systemplacenta   
 male systemprostate   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose   
Connectivebone   
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousastrocyte
Nervousglia
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two membrane-spanning domains and an amphipatic region pore,including the P domain with the K+ channel signature
  • an ATP-binding regulatory domain
  • mono polymer homomer , tetramer
    HOMOLOGY
    Homologene
    FAMILY potassium channel subfamily J
    CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • involved in the regulation of membrane potential
  • potassium non voltage-gated channel, inwardly rectifying
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component constituent with SUR2 of an ATP dependent potassium channel
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS