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FLASH GENE
Symbol KCNJ4 contributors: mct - updated : 27-10-2012
HGNC name potassium inwardly-rectifying channel, subfamily J, member 4
HGNC id 6265
Location 22q13.1      Physical location : 38.822.332 - 38.851.203
Synonym symbol(s) HIR, HIRK2, HRK1, IRK-3, IRK3, Kir2.3
DNA
TYPE functioning gene
STRUCTURE 28.87 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Map cen - GCAT - GALR3 - POLR2F - SOX10 - PICK1 - PLA2G6 - MAFF - CSNK1E - KCNJ4 - DDX17 - KDELR3 - DMC1 - GTPBP1 - D22S272 - DNAL4 - NPTXR - CBX6 - CBX7 - PDGFB - RPL3 - SYNGR1 - D22S1155 - MAP3K7IP1 - ATF4 - CACNA1I - D22S428 - qter
Authors Dunham (99)
Physical map
GALR3 22q13.1 galanin receptor 3 LOC129138 22q13.1 hypothetical protein BC014641 EIF3S6IP 22q12-q13 eukaryotic translation initiation factor 3, subunit 6 interacting protein MIRAB13 22q13.1-q13.2 molecule interacting with Rab13 C22orf23 22q13.1 chromosome 22 open reading frame 23 POLR2F 22q13.1 polymerase (RNA) II (DNA directed) polypeptide F SOX10 22q13.1 SRY (sex determining region Y)-box 10 LOC388899 22 LOC388899 PRKCABP 22q13.1 protein kinase C, alpha binding protein SLC16A8 22q12.3-q13.2 solute carrier 16 (monocarboxylic acid transporters), member 8 FLJ22582 22q13.1 hypothetical protein FLJ22582 PLA2G6 22q13.1-q13.32 phospholipase A2, group VI (cytosolic, calcium-independent) MAFF 22q13.1 v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian) C22orf5 22q12 chromosome 22 open reading frame 5 CSNK1E 22q13.1 casein kinase 1, epsilon KCNJ4 22q13.1 potassium inwardly-rectifying channel, subfamily J, member 4 KDELR3 22q13.1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3 DDX17 22q13.1 DEAD (Asp-Glu-Ala-Asp) box polypeptide 17 DMC1 22q13.1 DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination (yeast) LOC388900 22 LOC388900 TOMM22 22q12-q13 translocase of outer mitochondrial membrane 22 homolog (yeast) C22orf2 22q12 chromosome 22 open reading frame 2 KIAA0063 22q13.1 chromosome 22 open reading frame 2 GTPBP1 22q13.1 GTP binding protein 1 UNC84B 22q13.1-q13.3 unc-84 homolog B (C. elegans) DNAL4 22q13.1 dynein, axonemal, light polypeptide 4 LOC388901 22 LOC388901 NPTXR 22q13.1 neuronal pentraxin receptor CBX6 22q13.1 chromobox homolog 6
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 2075 - 445 - 2002 11997254
2 - 1913 - 445 - 2002 11997254
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Nervousbrainforebrain  highly Homo sapiens
Olfactory (smell)olfactory bulb     Mus musculus
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two membrane-spanning domains
  • an amphipatic region pore, including the P domain with the K+ channel signature and an ATP-binding regulatory domain
  • C-terminal KCNJ4-peptide binds much more strongly to TAX1BP3 than to mammalian LIN7A, LIN7B, LIN7C, indicating that TAX1BP3 can compete with mammalian LIN7 to uncouple KCNJ4 from its basolateral membrane anchoring complex
  • mono polymer homomer , tetramer
    HOMOLOGY
    Homologene
    FAMILY potassium channel subfamily J
    CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • potassium non voltage-gated channel,inwardly rectifying
  • KCNJ4- channels are marked for clathrin-dependent internalization from the plasma membrane by a novel TFAP2A-dependent signal
  • heteromeric assemblies of KCNJ2, KCNJ12 and KCNJ4 channels underly membrane potential stabilizing currents in ventricular myocytes, neurons and skeletal muscle
  • specifically targeted on the basolateral membranes of epithelial and neuronal cells, and it thus plays an important role in maintaining potassium homeostasis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • EDN1 inhibits human cardiac I(K1) current via a PKC-mediated phosphorylation of KCNJ12 channel subunits and additional regulatory effects on KCNJ4 channels
  • TAX1BP3 binding to KCNJ4 with a high affinity, causing the intracellular accumulation of KCNJ4 in cultured epithelial cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS