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FLASH GENE
Symbol KCNJ3 contributors: mct/pgu - updated : 27-09-2017
HGNC name potassium inwardly-rectifying channel, subfamily J, member 3
HGNC id 6264
Location 2q24.1      Physical location : 155.555.092 - 155.713.014
Synonym name
  • G protein coupled inwardly rectifying,potassium channel (GIRK1,Kir3.1)
  • inward rectifier K(+) channel Kir3.1
  • Synonym symbol(s) GIRK1, Kir3.1, KGA
    DNA
    TYPE functioning gene
    STRUCTURE 157.92 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked Y status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 2890 56.47 501 - 2001 11345517
    - splicing - - 309 - 2001 11345517
    - splicing - - 308 - 2001 11345517
    - splicing - - 235 - 2001 11345517
    - splicing - - 253 - 2001 11345517
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Endocrineadrenal glandcortex  highly Homo sapiens
    Nervousbrain    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two membrane-spanning domains (2TM)
  • an amphipatic region pore, including the P domain with the K+ channel signature
  • an ATP-binding regulatory domain
  • Gbetagamma-interacting segments in the first half of the C terminus
  • mono polymer homomer , tetramer
    HOMOLOGY
    Homologene
    FAMILY
  • inward rectifier-type potassium channel family
  • potassium channel subfamily J
  • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • playing a crucial role in regulating the heartbeat
  • important functional effector of the P2Y(12) receptor in platelets
  • having a critical role for depotentiation, one form of excitatory synaptic plasticity
  • KCNJ3 channel is involved in the TLR4-mediated signal at an early event by facilitating the recruitment of TLR4 into lipid raft
  • potentially playing a crucial role in TLR4-mediated signaling, presumably by facilitating the formation of signaling complex in the lipid raft
  • KCNJ3 channel plays a crucial role in the activation of NFKB induced by TLR4 and is thereby involved in the production of pro-inflammatory cytokines
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • KCNJ5 exists both as homotetramers and heterotetramers with KCNJ3 (KCNJ3 is inactive as a homotetramer)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • post-transcriptional regulation of GABBR1, GABBR2 and KCNJ3 channels by RTN4R
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in breast carcinoma suggesting its involvement in proliferation and oncogenesis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductivebreast
    therapy target in breast carcinoma
    ANIMAL & CELL MODELS