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FLASH GENE

Symbol

KCNJ3

contributors: mct/pgu - updated : 27-09-2017

HGNC name	potassium inwardly-rectifying channel, subfamily J, member 3
HGNC id	6264

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	2q24.1      Physical location : 155.555.092 - 155.713.014
Synonym name	G protein coupled inwardly rectifying,potassium channel (GIRK1,Kir3.1)
	inward rectifier K(+) channel Kir3.1
Synonym symbol(s)	GIRK1, Kir3.1, KGA

DNA

TYPE	functioning gene
STRUCTURE	157.92 kb     3 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

Y

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed GIRK1A 3 - 2890 56.47 501 - 2001 11345517 GIRK1B - splicing - - 309 - 2001 11345517 GIRK1C - splicing - - 308 - 2001 11345517 GIRK1D - splicing - - 235 - 2001 11345517 GIRK1E - splicing - - 253 - 2001 11345517

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Endocrine adrenal gland cortex     highly Homo sapiens Nervous brain

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	two membrane-spanning domains (2TM)
	an amphipatic region pore, including the P domain with the K+ channel signature
	an ATP-binding regulatory domain
	Gbetagamma-interacting segments in the first half of the C terminus

mono polymer

homomer , tetramer

HOMOLOGY

Homologene

FAMILY	inward rectifier-type potassium channel family
	potassium channel subfamily J

CATEGORY

transport channel

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	playing a crucial role in regulating the heartbeat
	important functional effector of the P2Y(12) receptor in platelets
	having a critical role for depotentiation, one form of excitatory synaptic plasticity
	KCNJ3 channel is involved in the TLR4-mediated signal at an early event by facilitating the recruitment of TLR4 into lipid raft
	potentially playing a crucial role in TLR4-mediated signaling, presumably by facilitating the formation of signaling complex in the lipid raft
	KCNJ3 channel plays a crucial role in the activation of NFKB induced by TLR4 and is thereby involved in the production of pro-inflammatory cytokines

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

KCNJ5 exists both as homotetramers and heterotetramers with KCNJ3 (KCNJ3 is inactive as a homotetramer)

INTERACTION

DNA

RNA

small molecule

protein

post-transcriptional regulation of GABBR1, GABBR2 and KCNJ3 channels by RTN4R

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in breast carcinoma suggesting its involvement in proliferation and oncogenesis

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer reproductive breast therapy target in breast carcinoma

ANIMAL & CELL MODELS