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FLASH GENE
Symbol KCNJ16 contributors: npt/ - updated : 10-12-2014
HGNC name potassium inwardly-rectifying channel, subfamily J, member 16
HGNC id 6262
Location 17q23.1-q21.2      Physical location : 68.071.425 - 68.131.744
Synonym name
  • potassium non-voltage gated channel
  • inward rectifier K(+) channel Kir5.1
  • Synonym symbol(s) KIR5.1, BIR9, MGC33717
    DNA
    TYPE functioning gene
    STRUCTURE 60.32 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 4021 48 418 - -
    - - 3926 48 418 - -
    - - 4025 48 418 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinepancreas    
     thyroid    
    Nervousbrainhindbrain   
     brainmidbrain   
     braindiencephalon   
    Urinarykidneytubuleconvoluted tubuledistal tubule  Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Nervouscentral   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Urinaryepithelial cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • transmembrane protein with two membrane-spanning domains
  • an amphipatic region pore, including the P domain with the K+ channel signature
  • an ATP-binding regulatory domain
  • mono polymer homomer , heteromer , tetramer
    HOMOLOGY
    interspecies homolog to rattus Kir5.1
    Homologene
    FAMILY
  • inward rectifier-type potassium channel family
  • potassium channel subfamily J
  • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    basic FUNCTION
  • putative regulator of fluid and pH balance
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • forming heterotetramers with Kir4.1 (KCNJ10) and Kir4.2 (KCNJ15)
  • KCNJ10 and KCNJ16, form a heterotetramer in the basolateral membrane of the distal convoluted tubule (DCT)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS