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FLASH GENE
Symbol KCNJ14 contributors: mct/npt - updated : 02-03-2009
HGNC name potassium inwardly-rectifying channel, subfamily J, member 14
HGNC id 6260
Location 19q13      Physical location : 48.958.765 - 48.969.367
Synonym name ATP-sensitive inward rectifier potassium channel 14
Synonym symbol(s) KIR2.4, IRK4, MGC46111
DNA
TYPE functioning gene
STRUCTURE 10.60 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Map cen - D195S18 - KCNJ14 - D19S218 - qter
Authors Topert (00)
regionally located . in the same region than five other potassium channel gene KCNA7, KCNC2, KCNC3, KCNC4, KCNC6
RNA
TRANSCRIPTS type messenger
text variants 1 and 2 encode the same protein
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 3049 47.8 436 - Tennant (2006)
3 - 3120 47.8 436 - Tennant (2006)
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelial    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two membrane-spanning domains
  • an amphipatic region pore, including the P domain with the K+ channel signature
  • an ATP-binding regulatory domain
  • mono polymer homomer , tetramer
    HOMOLOGY
    interspecies homolog to rattus Rn.14528
    homolog to Drosophila Ir
    homolog to C.elegans irk-2
    Homologene
    FAMILY
  • inward rectifier-type potassium channel family
  • potassium channel subfamily J
  • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • control of the excitability of brain stem motoneurons
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS nervous system
    text voltage-gated potassium channel
    PATHWAY
    metabolism
    signaling neurotransmission
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS