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FLASH GENE

Symbol

KCNIP2

contributors: npt/mct - updated : 18-12-2010

HGNC name	Kv channel interacting protein 2
HGNC id	15522

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	10q24.32      Physical location : 103.585.731 - 103.603.677
Synonym name	cardiac voltage gated potassium channel modulatory subunit
	potassium channel interacting protein 2
	A-type potassium channel modulatory protein 2
Synonym symbol(s)	KCHIP2

DNA

TYPE	functioning gene
STRUCTURE	17.95 kb     10 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_173192 9 - 2509 NP_775284 - 252 brain, heart, spinal cord, thymus An, Pruunsild (2005) also called KChIP2.1 or variant 3 NM_173191 10 - 2563 NP_775283 - 270 brain,cerebral cortex, amygdala, putamen, hippocampus, thalamus Ohya, Pruunsild (2005) also called KChIP2.4 or KChIP2L or variant 2 exon 1a, 2a and 2b NM_014591 10 - 2608 NP_055406 - 285 - Pruunsild (2005) also called KChIP4.2 or variant 1 NM_173193 8 - 2434 NP_775285 - 227 - Deschenes, Pruunsild (2005) also called KChIP2S or variant 4 NM_173194 8 - 2090 NP_775286 - 225 - Deschenes, Pruunsild also called variant 5 NM_173195 8 - 2413 NP_775287 - 220 - 2005 16112838 also called KChIP2.2, KChIP2T or KChIP2S or variant 6 NM_173197 6 - 907 NP_775289 - 184 - 2005 16112838 also called KChIP2.5 or variant 7

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial barrier/lining

cells

System Cell Pubmed Species Stage Rna symbol Cardiovascular endothelial cell

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	four EF-Hands, calcium binding motif
	two types of Ca2+-binding sites, and only one type of Mg2+-binding site

HOMOLOGY

interspecies

homolog to Kcnip2

intraspecies

homolog to KCHIP1,KCHIP3

Homologene

FAMILY

recoverin family

CATEGORY

signaling , transport channel

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm

basic FUNCTION	may be regulating A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium
	involved in gene regulation
	direct regulator of the cardiac L-type Ca2+ current, multimodal regulator of cardiac ionic currents
	can attenuate cardiac hypertrophy possibly through modulation of intracellular calcium concentration and calcineurin/NFAT pathway

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

a component	complexing with KCND3
	integral subunit component of native Kv4 chain complex

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS