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FLASH GENE
Symbol KCNIP1 contributors: npt/mct - updated : 18-12-2010
HGNC name Kv channel interacting protein 1
HGNC id 15521
Location 5q35.1      Physical location : 169.780.880 - 170.163.634
Synonym name
  • vesicle APC-binding protein
  • A-type potassium channel modulatory protein 1
  • Synonym symbol(s) KCHIP1, VABP, MGC95
    DNA
    TYPE functioning gene
    STRUCTURE 382.75 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 2053 - 227 brain, cerebellum, spinal cord, testis 2005 16112838
    exon 1a
    8 - 2020 - 216 brain, cerebellum, spinal cord 2005 16112838
    exon 1b
    8 - 1518 - 225 - 2005 16112838
    - - 726 - 241 - 2005 16112838
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrainhindbraincerebellum predominantly Homo sapiens
     braindiencephalonhypothalamus predominantly Homo sapiens
     braindiencephalonthalamus highly Homo sapiens
     brainbasal nucleistriatum highly Homo sapiens
     brainlimbic systemhippocampus highly Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    NervousPurkinje cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • four EF-hand-like motifs (calcium binding motif), intact EF-hands 3 and 4 were crucial for the anchorage of KCNIP1 on membrane
  • mono polymer heteromer , complex
    HOMOLOGY
    interspecies ortholog to murine Kcnip1
    homolog to rattus Kcnip1
    homolog to Drosophila CG5890
    homolog to C.elegans F21A10.1
    Homologene
    FAMILY
  • recoverin/NCS subfamily of calcium-binding proteins
  • CATEGORY regulatory , transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • regulating subunit modulating Kv4 (potassium voltage dependant) channel activity and neuronal excitability
  • stimulate the traffic of KCND2 channels to the plasma membrane (Venn 2008)
  • might play pivotal roles in the GABAergic inhibitory system
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS nervous system
    PATHWAY
    metabolism
    signaling
    a component
  • KCND1, KCND2, KCND3 (alpha subunits)and KCNIP1
  • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
  • protein binding with phospholipid vesicles induced a change in the structure of KCNIP1 in the presence of phosphatidylserine
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS