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FLASH GENE
Symbol KCNH8 contributors: mct - updated : 04-03-2014
HGNC name potassium voltage-gated channel, subfamily H (eag-related), member 8
HGNC id 18864
Location 3p24.3      Physical location : 19.190.016 - 19.577.135
Synonym name
  • ELK channel 3
  • voltage-gated potassium channel subunit Kv12.1
  • ether-a-go-go-like potassium channel 1
  • ether-a-go-go-like potassium channel 3
  • Synonym symbol(s) Kv12.1, ELK, ELK1, elk3
    DNA
    TYPE functioning gene
    STRUCTURE 387.19 kb     20 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC344875 3p25.1 similar to RIKEN cDNA E330026B02 CAPN7 3p24 calpain 7 SH3BP5 1q43 SH3-domain binding protein 5 (BTK-associated) LOC389097 3 similar to Nonhistone chromosomal protein HMG-17 (High-mobility group nucleosome binding domain 2) MGC24132 3p25.1 hypothetical protein MGC24132 EAF1 3q25.1 ELL associated factor 1 COLQ 3p24.2 collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase HPCL2 3p25.1 2-hydroxyphytanoyl-CoA lyase BTD 3p25 biotinidase KIAA0379 3p25.2-p24.2 biotinidase LOC131961 3p25.1 similar to inosine monophosphate dehydrogenase 1 isoform a; sWSS2608 GALNT7 4q31.1 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 7 (GalNAc-T7) MGC15763 3p25-p24 hypothetical protein BC008322 RAFTLIN 3p25.1 raft-linking protein DAZL 3p24 deleted in azoospermia-like PLCL2 3p24.3 phospholipase C-like 2 TBC1D5 3p24.3 TBC1 domain family, member 5 LOC151842 3p24.3 inorganic pyrophosphatase pseudogene LOC391516 3 similar to IAP-associated factor VIAF1; phosducin-like 2 SATB1 3p24.3-p23 special AT-rich sequence binding protein 1 (binds to nuclear matrix/scaffold-associating DNA's) LOC389098 3 LOC389098 LOC131185 3p24.3 similar to UV excision repair protein RAD23 homolog B (HHR23B) (XP-C repair complementing complex 58 kDa protein) (P58) KCNH8 3p24.3 potassium voltage-gated channel, subfamily H (eag-related), member 8 FLJ25200 3p24.3 hypothetical protein FLJ25200 RAB5A 3p24-p22 RAB5A, member RAS oncogene family LOC391517 3 similar to Heat shock cognate 71 kDa protein FLJ25449 3p24.3 hypothetical protein MGC27069 PCAF 3p24 p300/CBP-associated factor LOC151648 3p24.3 hypothetical protein BC001339 LOC391518 3 hypothetical gene supported by X74864 FLJ22419 3p24.3 hypothetical protein FLJ22419 LOC389099 3 similar to RIKEN cDNA B830010L13 gene HMG1L5 3p24 high-mobility group (nonhistone chromosomal) protein 1-like 5 LOC391519 3 similar to SALL4B
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    16 - 5106 123.7 1107 - 2003 12890647
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal cytoplasmic domain, containing an EAG domain, which is composed of a Per-Arnt-Sim (PAS) dimerization domain and a PAS-cap domain,
  • PAC (PAS-associated C-terminal) domain
  • six transmembrane domains the fourth being the voltage-sensor site
  • a pore forming domain (H5) between the fifth and sixth transmembrane domains
  • two N-glycosylation site
  • C-terminal region containing a cyclic-nucleotide-binding homology domain (CNBHD) and C-linker that couples the CNBHD to the pore
  • mono polymer homomer , heteromer , tetramer
    HOMOLOGY
    Homologene
    FAMILY
  • potassium channel family
  • H (EAG) subfamily
  • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    basic FUNCTION
  • pore forming (alpha) subunit of voltage-gated potassium channel
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS facilitated diffusion transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • cyclic nucleotide (cAMP)
  • protein
  • CACNA2D2 and KCNH8, appeared to be regulated by CTNNB1, although the binding of CTNNB1 to the regulatory sequences of these genes could not be confirmed
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS