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FLASH GENE
Symbol KCNH7 contributors: mct/npt - updated : 05-03-2014
HGNC name potassium voltage-gated channel, subfamily H (eag-related), member 7
HGNC id 18863
Location 2q24.2      Physical location : 163.227.916 - 163.695.240
Synonym name
  • eag related protein 3
  • voltage-gated potassium channel subunit Kv11.3
  • potassium channel subunit HERG-3
  • ether-a-go-go related gene potassium channel 3
  • voltage-gated potassium channel subunit Kv11.3
    Synonym symbol(s) HERG3, HERG-3, Kv11.3, MGC45986
    DNA
    TYPE functioning gene
    STRUCTURE 467.32 kb     16 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    OR7E89P 2q31.3 olfactory receptor, family 7, subfamily E, member 89 pseudogene LOC391457 2 similar to putative taste receptor HTR2 OR7E90P 2q31.3 olfactory receptor, family 7, subfamily E, member 90 pseudogene MGC23908 2 similar to RNA polymerase B transcription factor 3 KIAA1728 2q24.2 KIAA1728 protein FLJ36175 2q24.2 hypothetical protein FLJ36175 BAZ2B 2q23-q24 bromodomain adjacent to zinc finger domain, 2B AXOT 2q24.2 axotrophin DCL-1 2q24.2 type I transmembrane C-type lectin receptor DCL-1 LY75 2p24 lymphocyte antigen 75 PLA2R1 2q23-q24.1 phospholipase A2 receptor 1, 180kDa ITGB6 2q24-q31 integrin, beta 6 RBMS1 2q24.2 RNA binding motif, single stranded interacting protein 1 TANK 2q24-q31 TRAF family member-associated NFKB activator PSMD14 2q24.3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 TBR1 2q24 T-box, brain, 1 LOC285116 2q24.3 ELYS transcription factor-like protein TMBS62 pseudogene LOC391458 2 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) SLC4A10 2q23-q24 solute carrier family 4, sodium bicarbonate transporter-like, member 10 DPP4 2q24.3 dipeptidylpeptidase 4 (CD26, adenosine deaminase complexing protein 2) GCG 2q36-q37 glucagon FAP 2q23 fibroblast activation protein, alpha MDA5 2p24.3-q24.3 melanoma differentiation associated protein-5 GCA 2q24.3 grancalcin, EF-hand calcium binding protein KCNH7 2q24.3 potassium voltage-gated channel, subfamily H (eag-related), member 7 FIGN 2q24.2 fidgetin GRB14 2q22-q24 growth factor receptor-bound protein 14 KIAA0977 2q24.3 growth factor receptor-bound protein 14 FLJ39822 2q24.3 hypothetical protein FLJ39822 SCN3A 2q24.3 sodium channel, voltage-gated, type III, alpha SCN2A2 2q23-q24.3 sodium channel, voltage-gated, type II, alpha 2 TAIP-2 2q24.3 TGF-beta induced apotosis protein 2 GALNT3 2q24-q31 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    16 splicing polyA site codon stop 4225 135 1196 - 1999 1041430
    8 splicing polyA site codon stop 2488 - 732 - 1999 1041430
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    nervousbraindiencephalon   
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    cell lineage
    cell lines prolactine adenoma
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal cytoplasmic domain
  • PAS (PER-ARNT-SIM) dimerization domain
  • PAC (PAS-associated C-terminal ) domain
  • six transmembrane domains the fourth being the voltage-sensor site
  • a pore forming domain (H5) between the fifth and sixth transmembrane domains
  • a N glycosylation site
  • C-terminal region containing a cyclic-nucleotide-binding homology domain (CNBHD) and C-linker that couples the CNBHD to the pore
  • conjugated GlycoP
    mono polymer homomer , heteromer , tetramer
    HOMOLOGY
    Homologene
    FAMILY
  • potassium channel family
  • H (EAG) subfamily
  • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • pore forming (alpha) subunit of voltage-gated potassium channel
  • selectively involved in proliferation of distinct uterine cancer cells (Suzuki 2004)
  • forms the ion channel responsible for the rapidly acting delayed rectifier potassium current, I(Kr), and its blockade is a significant contributor to prolongation of the QT interval (Yoshida 2006)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS facilitated diffusion transport
    text prolactine secretion
    PATHWAY
    metabolism
    signaling
    a component
  • KCNH2, KCNH6
  • part of ERG channels control the excitability of medial vestibular nucleus neurones, their discharge regularity and probably their resonance properties (Pessia 2008)
  • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • cyclic nucleotide (cAMP)
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS