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FLASH GENE
Symbol KCNG4 contributors: - updated : 13-04-2004
HGNC name potassium voltage-gated channel, subfamily G, member 4
HGNC id 19697
Location 16q24.1      Physical location : 84.255.824 - 84.273.356
Synonym name voltage-gated potassium channel Kv6.3
Synonym symbol(s) Kv6.4, Kv6.3, MGC4558
DNA
TYPE functioning gene
STRUCTURE 17.00 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
HSBP1 16q23.3 heat shock factor binding protein 1 MLYCD 16q23-q24 malonyl-CoA decarboxylase OKL38 16q24.1 malonyl-CoA decarboxylase NECAB2 LOC146167 16q24.1 similar to hypothetical protein FLJ10815 MBTPS1 16q24 membrane-bound transcription factor protease, site 1 LOC390743 16 similar to Serine/Threonine protein kinase LOC83693 16q24.1 steroid dehydrogenase-like LOC123872 16q24.1 similar to RIKEN cDNA 4930457P18 TAF1C 16q24 TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa LOC161931 16q24.1 testis nuclear RNA-binding protein-like KCNG4 16q24.1 potassium voltage-gated channel, subfamily G, member 4 LOC388302 16 LOC388302 WFDC1 16q24.3 WAP four-disulfide core domain 1 KIAA0703 16q24.2 WAP four-disulfide core domain 1 KIAA1609 16q24.1 KIAA1609 protein COTL1 16q24.1 coactosin-like 1 (Dictyostelium) C16orf44 16q24.1 chromosome 16 open reading frame 44 USP10 16q24.1 ubiquitin specific protease 10 DKFZP434B044 16q24.1 hypothetical protein DKFZp434B044 LOC123862 16q24.1 similar to Interferon-induced transmembrane protein 3 (Interferon-inducible protein 1-8U) ZDHHC7 16q23.3 zinc finger, DHHC domain containing 7 KIAA0513 16q24.1 KIAA0513 gene product FLJ44299 16q24.1 FLJ44299 protein LOC123855 16q24.1 similar to ENSANGP00000013733 MGC22001 16q24.1 hypothetical protein MGC22001 LOC388303 16 LOC388303 LOC388304 16 LOC388304
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 1681 58 519 - Ottschytsch et al. (02)
encodes the longest isoform
- splicing 2233 - 256 - Ottschytsch et al. (02)
variant 2 has an alternate 3' sequence resulting in an isoform 2 shorter and distinct in the C terminus
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  lowly
 intestinelarge intestinecolon lowly
 liver   lowly
Nervousbrain   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
K+ channel tetramerisation domain
mono polymer heteromer , tetramer
HOMOLOGY
Homologene
FAMILY K+ channel family, G subfamily
CATEGORY regulatory , transport channel
SUBCELLULAR LOCALIZATION     plasma membrane
text remains intracellular in the absence of KCNB1
basic FUNCTION
  • modulates channel activity by shifting the treshold and the half-maximal activation to more negative values
  • controls the excitability of electrically active cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein heteromultimerizing with KCNB1, KCNC1 and KCNF1 to form the K+ channel
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS