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FLASH GENE
Symbol KCNG3 contributors: mct - updated : 24-06-2014
HGNC name potassium voltage-gated channel, subfamily G, member 3
HGNC id 18306
Location 2p22.1      Physical location : 42.669.158 - 42.721.237
Synonym name
  • voltage-gated potassium channel 6.3
  • voltage-gated potassium channel Kv10.1
    • Synonym symbol(s) KV6.3, KV10.1
    DNA
    TYPE functioning gene
    STRUCTURE 52.00 kb     2 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 3824 49.6 436 highly in brain,pancreas,testis lowly in lung,kidney,thymus,ovary,small intestine and colon Ottschytsch,Sano
    - - 3791 - 425 - Ottschytsch,Sano
    lacking an internal segment
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal cytoplasmic domain
  • six transmembrane domains,the fourth being probably the voltage sensor
  • a pore forming domain between the fifth and sixth transmembrane domains
    • mono polymer heteromer , tetramer
    HOMOLOGY
    interspecies homolog to rattus Kcng3
    Homologene
    FAMILY
  • potassium channel family, G subfamily
    • CATEGORY regulatory , transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    basic FUNCTION
  • potassium channel subunit modulating channel activity
  • mediating the voltage-dependent potassium ion permeability of excitable membranes.
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS facilitated diffusion transport
    PATHWAY
    metabolism
    signaling
    a component
  • forming potassium channels only if heteromultimerized
  • KCNB1 or KCNC1 or KCNF1
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by BMP2 that significantly (>2-fold) upregulated mRNA expression of KCNG3
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS