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FLASH GENE

Symbol

KCNG2

contributors: mct - updated : 24-06-2014

HGNC name	potassium voltage-gated channel, subfamily G, member 2
HGNC id	6249

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	18q23      Physical location : 77.623.667 - 77.659.815
Synonym name	cardiac potassium channel subunit
	voltage-gated potassium channel subunit Kv6.2
Synonym symbol(s)	KCNF2, Kv6.2

DNA

TYPE	functioning gene
STRUCTURE	36.15 kb     2 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_012283 2 - 1401 NP_036415 51.1 466 - 1999 10551266

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular cardiac myocardium     Muscular smooth       Muscular striatum cardiac

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	transmembrane protein with six putative membrane-spanning domains
	an hydrophobic pore including the P domain
	the K+ channel signature
	TM domains 5 and 6, sensitive to changes in membrane potential

HOMOLOGY

interspecies

homolog to rattus Kv6.2

Homologene

FAMILY	potassium channel family
	G subfamily

CATEGORY

transport channel

SUBCELLULAR LOCALIZATION	extracellular
	plasma membrane

basic FUNCTION

potassium voltage-gated channel

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

repressed by

BMP2 that significantly (>2-fold) downregulated mRNA expression of KCNAB1 9)

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS