protein
| may coassemble with KCNQ subunits |
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has a dramatic inhibitory effect on KCNQ1 that differs substantially from the activating effects of KCNE1 and KCNE3  |
|
associates with KCNA3 in the ER and decreases the number of KCNA3 channels at the cell surface, which diminishes cell excitability  |
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modulate KCND current activation, inactivation and recovery from inactivation, in a KCNIP2-dependent manner  |
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can biochemically interact with CALM1 and this interaction is Ca(2+)-dependent and requires a tetraleucine motif in the juxtamembrane region of the KCNE4 C terminus  |
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interaction between KCNE4 and CALM1 could be involved in the modulation of KCNQ1 by KCNE4  |
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CALM1-KCNE4 interactions might constitute part of a feedback loop for regulating intracellular Ca2+  |