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FLASH GENE
Symbol KCNB2 contributors: mct/npt - updated : 07-02-2009
HGNC name potassium voltage-gated channel, Shab-related subfamily, member 2
HGNC id 6232
Location 8q13.2      Physical location : 73.449.625 - 73.850.582
Synonym name
  • voltage-gated potassium channel subunit Kv2.2
  • delayed rectifier potassium channel protein
  • Synonym symbol(s) KV2.2
    DNA
    TYPE functioning gene
    SPECIAL FEATURE arranged in tandem
    STRUCTURE 401.00 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    motif repetitive sequence
    MAPPING cloned Y linked N status confirmed
    Map cen - D8S279 - KCNB2 - D8S526 - qter
    Authors Gene Map (98)
    Physical map
    VEST1 8q13 vestibule-1 protein LOC389667 8 similar to tropomyosin 4 SULF1 8q13.1 similar to tropomyosin 4 SLCO5A1 8q13.2 solute carrier family 21 (organic anion transporter), member 15 LOC392230 8 similar to BAG-family molecular chaperone regulator-4 (Silencer of death domains) PRDM14 8p21-p12 PR domain containing 14 LOC346990 8q13.2 similar to H2A histone family, member Z NCOA2 8q13.1 nuclear receptor coactivator 2 LOC392231 8 similar to basic transcription factor 3 TRAM1 8q13.1 translocation associated membrane protein 1 CGI-83 LOC389668 8 similar to hypothetical protein FLJ10307 EYA1 8q13.3 eyes absent homolog 1 (Drosophila) MSC 8q21.1-q21.2 musculin (activated B-cell factor-1) TRPA1 8q13 transient receptor potential cation channel, subfamily A, member 1 LOC392232 8 similar to ankyrin-like protein 1; ankyrin-like with transmembrane domains 1 KCNB2 8q13.2 potassium voltage-gated channel, Shab-related subfamily, member 2 TERF1 8q13 telomeric repeat binding factor (NIMA-interacting) 1 RPESP 8q13.3 RPE-spondin LOC392233 8 similar to Hspcb protein LOC389669 8 LOC389669 RPL7 8q12-q22 ribosomal protein L7 RDH10 8q13.3 retinol dehydrogenase 10 (all-trans) STAU2 8q13-q21.1 staufen, RNA binding protein, homolog 2 (Drosophila) FLJ11011 8q13.3 hypothetical protein FLJ11011 TCEB1 8q13-q21 transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C) FLJ20533 8q13.3 hypothetical protein FLJ20533 LOC157793 8q13.3 similar to destrin - pig LY96 8q13.3 lymphocyte antigen 96 JPH1 8q21 junctophilin 1 GDAP1 8q13.3-q21 ganglioside-induced differentiation-associated protein 1 LOC286157 8q13.3 similar to mCBP PI15 8q13.3 protease inhibitor 15 LOC83690 8q13.3 CocoaCrisp LOC389670 8 hypothetical gene supported by BC062758 LOC392234 8 similar to Pyruvate kinase, M2 isozyme HNF4G 8q21.3-q22.1 hepatocyte nuclear factor 4, gamma MRPL9P1 8q21.11 mitochondrial ribosomal protein L9 pseudogene
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 3597 102.5 911 - Schmalz (1998)
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinepancreas    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularexocrine 
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Endocrineislet cell (alpha,beta...)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • six putative membrane-spanning domains
  • an hydrophobic pore including the P domain with the K+ channel signature
  • TM domains 5 and 6, sensitive to changes in membrane potential
  • HOMOLOGY
    interspecies homolog to Drosophila Shab-related subfamily
    Homologene
    FAMILY
  • potassium channel, voltage-gated, shab-related subfamily
  • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • involved in repolarization of excitable cells (Yan 2004)
  • playing a role in regulating the excitability of superior cervical ganglion neurons (Malin 2002)
  • KCNB1 regulates insulin secretion in beta-cells and KCNB2 modulates somatostatin release in delta-cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other modulated by KCNS2
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS