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FLASH GENE
Symbol KCNB2 contributors: mct/npt - updated : 21-01-2020
HGNC name potassium voltage-gated channel, Shab-related subfamily, member 2
HGNC id 6232
Location 8q21.11      Physical location : 73.449.625 - 73.850.582
Synonym name
  • voltage-gated potassium channel subunit Kv2.2
  • delayed rectifier potassium channel protein
  • Synonym symbol(s) KV2.2
    DNA
    TYPE functioning gene
    SPECIAL FEATURE arranged in tandem
    STRUCTURE 408.67 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    motif repetitive sequence
    MAPPING cloned Y linked N status confirmed
    Map cen - D8S279 - KCNB2 - D8S526 - qter
    Authors Gene Map (98)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 3748 102.5 911 - 2012 22422395
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinepancreas    
    Nervousbrain     Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularexocrine 
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Endocrineislet cell (alpha,beta...)
    Nervouspyramidal cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • six putative membrane-spanning domains
  • an hydrophobic pore including the P domain with the K+ channel signature
  • TM domains 5 and 6, sensitive to changes in membrane potential
  • HOMOLOGY
    interspecies homolog to Drosophila Shab-related subfamily
    Homologene
    FAMILY
  • potassium channel, voltage-gated, shab-related subfamily
  • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • involved in repolarization of excitable cells (Yan 2004)
  • playing a role in regulating the excitability of superior cervical ganglion neurons (Malin 2002)
  • kCNB1, KCNB2 are important regulators of neuronal excitability in mammalian brain
  • KCNB1 regulates insulin secretion in beta-cells and KCNB2 modulates somatostatin release in delta-cells
  • KCNB1, KCNB2 exhibit distinct responses to acute phosphorylation-dependent regulation in brain neurons in situ
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • key function of the pyruvate-isocitrate cycle is to maintain levels of KCNB2 expression sufficient to allow it to serve as a negative regulator of Kv channel activity
  • cell & other
    REGULATION
    Other modulated by KCNS2
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS