| basic FUNCTION
| mediating the voltage-dependent potassium ion permeability of excitable membranes |
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possible involvement in pituitary cell excitability and secretory activity regulated by osmolarity |
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regulates pancreatic beta-cell excitability and insulin secretion  |
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a role of KCNB1 is to communicate membrane potential to cytoplasmic signaling systems much like L-type Ca2+ channels link plasma membrane potential to cytoplasmic sarcoplasmic reticulum Ca2+ release in skeletal muscle |
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KCNB1, KCNB2 are important regulators of neuronal excitability in mammalian brain |
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important in the brain for determining activity-dependent excitability |
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in most central neurons, plays a key role in regulating neuronal membrane excitability |
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regulates insulin secretion in beta-cells and KCNB2 modulates somatostatin release in delta-cells |
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accumulation of KCNB1 oligomers in the membrane disrupts planar lipid raft integrity and causes apoptosis via activating the SRC/JNK signaling pathway |
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homeostatic suppression of elevated neuronal activity by KCNB1 plays potentially a central role in regulating neuronal network function |
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conducts a major delayed rectifier current in the brain, pancreas and cardiovascular system and is a key player in apoptotic programs associated with oxidative stress |
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primary delayed-rectifier K(+) channel in the mammalian brain, induces the formation of ER-plasma-membrane junctions |
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KCNB1-induced ER-plasma-membrane junctions functions as a scaffolding site for both membrane trafficking and Ca(2+) signaling |
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KCNB1, KCNB2 exhibit distinct responses to acute phosphorylation-dependent regulation in brain neurons in situ |
