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FLASH GENE

Symbol

KCNA7

contributors: mct - updated : 24-06-2014

HGNC name	potassium voltage-gated channel, shaker-related subfamily, member 7
HGNC id	6226

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	19q13.4      Physical location : 49.570.675 - 49.576.198
Synonym symbol(s)	HAK6, KV1-7

DNA

TYPE	functioning gene
STRUCTURE	5.00 kb     2 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

Map	cen - GYS1 - KCNA7 - HRC - KCNC3 - qter
Authors	Kalman (98)

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       predominantly Digestive liver       lowly Urinary kidney       predominantly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum cardiac     Muscular striatum skeletal

cells

System Cell Pubmed Species Stage Rna symbol Endocrine islet cell (alpha,beta...)

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	six putative membrane-spanning domains
	an hydrophobic pore including the P domain with the K+ channel signature,flanked by
	TM domains 5 and 6, sensitive to changes in membrane potential

mono polymer

tetramer , complex

HOMOLOGY

interspecies	ortholog to murine Kv1.7
	homolog to Drosophila shaker-related subfamily

Homologene

FAMILY

potassium channel, voltage-gated, shaker-related subfamily

CATEGORY

transport channel

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION

regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

tetramer forming a complex through its cytoplasmic segment T1 facing the membrane pore with four beta subunits forming the associated cytoplasmic auxiliary subunits

INTERACTION

DNA

RNA

small molecule

protein

associating with the N terminus region of alpha subunit

cell & other

REGULATION

activated by

BMP2 that significantly (>2-fold) upregulated mRNA expression of KCNA7

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS