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FLASH GENE
Symbol KCNA4 contributors: - updated : 19-05-2006
HGNC name potassium voltage-gated channel, shaker-related subfamily, member 4
HGNC id 6222
Location 11p14.1      Physical location : 30.031.765 - 30.038.488
Synonym symbol(s) HuK2, KV1.4, HK1, PCN2, KCNA8, KCNA4L
DNA
TYPE functioning gene
STRUCTURE 6.00 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Map pter - D11S155 - KCNA4 - D11S301 - D11S298 - FSHB FSHB - MPPED2 - D11S16 - D11S315 - cen
Authors Gessler (92), Gawin (95)
Physical map
BBOX1 11p14.1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 NY-REN-41 11p14.2 NY-REN-41 antigen GPR48 11p14-p13 G protein-coupled receptor 48 LIN7C 11p14 lin-7 homolog C (C. elegans) LOC283114 11p14.2 similar to 40S ribosomal protein S25 BDNF 11p14 brain-derived neurotrophic factor LOC159770 11p14.1 chromobox homolog 3 gamma pseudogene HSPCAL3 11p14.2-p14.1 heat shock 90kDa protein 1, alpha-like 3 DKFZP434G2226 11p14.1 kinesin family member 18A FLJ33979 11p14.1 hypothetical protein FLJ33979 LOC390104 11 similar to eukaryotic translation elongation factor 1 alpha 1-like 14 KCNA4 11p14.1 potassium voltage-gated channel, shaker-related subfamily, member 4 FSHB 11p13 follicle stimulating hormone, beta polypeptide FLJ38968 11p14.1 hypothetical protein FLJ38968 C11orf8 11p13 chromosome 11 open reading frame 8 LOC387759 11 LOC387759 FLJ46154 11p14.1 FLJ46154 protein LOC341019 HCP25 11p13 cytochrome c, somatic pseudogene LOC120526 11p14.1 hypothetical protein LOC120526 FLJ25059 11p14.1 hypothetical protein FLJ25059 ELP4 11p13 elongation protein 4 homolog (S. cerevisiae) PAX6 11p13 paired box gene 6 (aniridia, keratitis) RCN1 11p13 reticulocalbin 1, EF-hand calcium binding domain LOC390105 11 similar to RIKEN cDNA 0610012H03 WT1 11p13 Wilms tumor 1 WIT-1 11p13 Wilms tumor associated protein LOC387760 11 LOC387760 GA17 11p13 LOC387760 RPL34P2 11p13 ribosomal protein L34 pseudogene 2
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Respiratorylung   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • transmembrane (TM) protein with six putative membrane-spanning domains
  • an hydrophobic pore including the P domain with the K+ channel signature,flanked by TM domains 5 and 6, sensitive to changes in membrane potential
  • mono polymer tetramer , complex
    HOMOLOGY
    interspecies homolog to murine Kv1.4
    homolog to Drosophila shaker-related subfamily
    Homologene
    FAMILY potassium channel, voltage-gated, shaker-related subfamily
    CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION mediating the voltage-dependent potassium ion permeability of excitable membranes
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS facilitated diffusion transport
    PATHWAY
    metabolism
    signaling
    a component
  • tetramer forming a complex through its cytoplasmic segment T1 facing the membrane pore with four beta subunits forming the associated cytoplasmic auxiliary subunits
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • associating with the N terminus region of alpha subunit
  • interaction with ACTN2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS