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FLASH GENE
Symbol KCNA4 contributors: - updated : 19-05-2006
HGNC name potassium voltage-gated channel, shaker-related subfamily, member 4
HGNC id 6222
Location 11p14.1      Physical location : 30.031.765 - 30.038.488
Synonym symbol(s) HuK2, KV1.4, HK1, PCN2, KCNA8, KCNA4L
DNA
TYPE functioning gene
STRUCTURE 6.00 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Map pter - D11S155 - KCNA4 - D11S301 - D11S298 - FSHB - MPPED2 - D11S16 - D11S315 - cen
Authors Gessler (92), Gawin (95)
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Respiratorylung   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • transmembrane (TM) protein with six putative membrane-spanning domains
  • an hydrophobic pore including the P domain with the K+ channel signature,flanked by TM domains 5 and 6, sensitive to changes in membrane potential
    • mono polymer tetramer , complex
    HOMOLOGY
    interspecies homolog to murine Kv1.4
    homolog to Drosophila shaker-related subfamily
    Homologene
    FAMILY potassium channel, voltage-gated, shaker-related subfamily
    CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION mediating the voltage-dependent potassium ion permeability of excitable membranes
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS facilitated diffusion transport
    PATHWAY
    metabolism
    signaling
    a component
  • tetramer forming a complex through its cytoplasmic segment T1 facing the membrane pore with four beta subunits forming the associated cytoplasmic auxiliary subunits
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • associating with the N terminus region of alpha subunit
  • interaction with ACTN2
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS