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FLASH GENE
Symbol KBTBD3 contributors: np/ - updated : 14-01-2004
HGNC name kelch repeat and BTB (POZ) domain containing 3
HGNC id 22934
Location 11q22.3      Physical location : 105.921.825 - 105.948.465
Synonym name BTB and kelch domain containing 3
Synonym symbol(s) BKLHD3, FLJ30685
DNA
TYPE functioning gene
SPECIAL FEATURE antisens
text antisense to AASDHPPT over 382 bp
STRUCTURE 26.64 kb     4 Exon(s)
MAPPING cloned Y linked N status provisional
Physical map
SCDGF-B CASP12P1 11q22.3 caspase 12 pseudogene 1 CASP4 11q22.2-q22.3 caspase 4, apoptosis-related cysteine protease CASP5 11q22.2-q22.3 caspase 5, apoptosis-related cysteine protease CASP1 11q22.2-q22.3 caspase 1, apoptosis-related cysteine protease (interleukin 1, beta, convertase) COP  clathrin-ordered protein ICEBERG 11q21-q22 ICEBERG caspase-1 inhibitor OR2AL1P 11q23.3 olfactory receptor, family 2, subfamily AL, member 1 pseudogene GRIA4 11q22.3 glutamate receptor, ionotrophic, AMPA 4 KIAA1826 11q22 KIAA1826 protein KBTBD3 11q22.3 kelch repeat and BTB (POZ) domain containing 3 AASDHPPT 11q22 aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase GUCY1A2 11q21-q22 guanylate cyclase 1, soluble, alpha 2 LOC341230 11q23.1 similar to argininosuccinate synthetase FLJ32343 11q23.1 hypothetical protein FLJ32343 LOC91801 11q23.1 hypothetical protein BC015183 DKFZp547C176 11q23.1 hypothetical protein DKFZp547C176 SLN 11q22-q23 sarcolipin LOC203930 11q23.1 sorting nexin 7 pseudogene SLC35F2 11q23.1 solute carrier family 35, member F2 RAB39 11q22-q23 RAB39, member RAS oncogene family CUL5 11q22-q23 cullin 5 ACAT1 11q22.3 acetyl-Coenzyme A acetyltransferase 1 (acetoacetyl Coenzyme A thiolase) NPAT 11q22-q23 nuclear protein, ataxia-telangiectasia locus
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 4030 69 612 - -
4 - 4231 69 612 - -
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen    
Nervousbrain    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Lymphoid    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one BTB/POZ domain
  • six kelch repeat motifs
  • HOMOLOGY
    interspecies homolog to murine Bklhd3
    Homologene
    FAMILY
  • BTB/POZ domain and Kelch repeat family
  • CATEGORY regulatory , structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    text interacts with actin cytoskeleton
    basic FUNCTION
  • actin-binding protein involved in the regulation of neuronal process formation and in differenciation of neural crest cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • actin binding
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS