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FLASH GENE
Symbol KAT8 contributors: mct - updated : 07-03-2015
HGNC name K(lysine) acetyltransferase 8
HGNC id 17933
Location 16p11.2      Physical location : -
Synonym name
  • male absent on the first
  • MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1
  • ortholog of Drosophila males absent on the first (MOF)
  • MYST histone acetyltransferase 1
    • Synonym symbol(s) MOF, hMOF, FLJ14040, MYST, MYST1
    EC.number 2.3.1.48
    DNA
    TYPE functioning gene
    STRUCTURE 13.73 kb     11 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 1548 52.4 458 - 2000 10786633
    10 - 1840 - 467 - 2000 10786633
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveintestinelarge intestinecolon highly
    Lymphoid/Immunelymph node   moderately
    Nervousbrain   moderately
    Reproductivefemale systemplacenta  moderately
     female systemovary  highly
     male systemprostate  lowly
    Respiratoryrespiratory tractlarynx  predominantly
    Skin/Tegumentskin   moderately
    Visualeye   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Connectivebone   
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion blood
    at STAGE
    physiological period embryo, pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one chromatin domain
  • chromatin organization modifier domain
  • acetyltransferase domain
  • PHD domain
  • a C2HC-type zinc finger
    • HOMOLOGY
    interspecies homolog to Drosophila mof
    ortholog to murine Myst1
    Homologene
    FAMILY
  • MYST family (MOZ-SAS family)
    • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome,kinetochore
    intracellular,nuclear envelope
    basic FUNCTION
  • acting as an histone acetyltransferase involved in transcriptional activation
  • required specifically for the maintenance of H4K16 acetylation and normal chromatin architecture of all cells of early male and female embryos
  • through H4K16ac (histone code), has a critical role at multiple stages in the cellular DNA damage response and DSB repair
  • major enzyme to catalyze acetylation of histone H4 lysine 16 (K16) and is highly conserved through evolution
  • involved in H4 K16 acetylation and playing an important roles in DNA damage repair by modulating recruitment of DNA damage repair protein MDC1
  • modulates proliferation and metastasis by regulating histone H4K16 acetylation at the promoter regions of downstream target genes
  • major enzyme that catalyzes the acetylation of histone H4 on lysine 16
  • play an essential role in maintaining normal cell functions
  • KAT8-mediated NFE2L2 acetylation and nuclear retention are essential for anti-oxidative and anti-drug responses
  • participates in human hepatocellular carcinoma by targeting SIRT6
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • member of the MYST (Moz-Ybf2/Sas3-Sas2-Tip60) family of histone acetyltransferases (HATs), a second HAT complex, designated the non-specific lethal (NSL) complex
    • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
    • protein
  • chromodomain of MORF4L1/MRG15
  • ATM
  • MLL C-terminal domain
  • BAZ2A is acetylated by acetyltransferase KAT8(males absent on the first)
  • MSL3 interact directly with MYST1 via its conserved C-terminal MRG domain
  • SIRT1 was found to interact with the MYST domain of KAT8 through the deacetylase catalytic region and deacetylate autoacetylated
  • orchestrates H4K16 acetylation and H3K4 trimethylation for activation of multiple genes by recruiting KAT8 and causing displacement of KDM5B
  • SIRT1 deacetylation of the enzymatic domains of KAT8 and KAT5 inhibits their acetyltransferase activity and promotes ubiquitination-dependent degradation of these proteins
  • KAT8 binding and acetylation of CCAR2 are inhibited after DNA damage in an ATM-dependent fashion, contributing to increased SIRT1-CCAR2 binding after DNA damage
  • interplay between MSH4 and KAT8 manipulates the outcomes of nonhomologous end joining (NHEJ)-mediated DNA double strand break (DSB) repair and thereby controls cell survival in response to ionizing radiation (IR)
  • MSL1 regulates global histone H4 acetylation at residue K16 in stem and cancer cells, through interaction with KAT8
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in non-small cell lung cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerdigestiveliver
    KAT8 activators may serve as potential drug candidates for hepatocellular carcinoma therapy
    cancerlung 
    may provide a therapeutic target for the treatment of NSCLC
    ANIMAL & CELL MODELS