basic FUNCTION
| regulation of AR-dependent genosin in normal and prostate cancer cells |
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positive regulatory factor for pre-RC (prereplicative complex) assembly |
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may be involved in the regulation of eukaryotic transcription |
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can acetylate nucleosomal histone H4 |
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transcriptional coactivator |
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associating with replication origins specifically during the G1 phase of the cell cycle in a manner that depends on the replication licensing factor CDT1 |
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integrates internal and external stimuli to coordinate transcriptional responses with initiation of DNA replication |
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H4-specific histone acetylase, is a coactivator of the DNA replication licensing factor CDT1 |
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primary role in development is that of a transcriptional activator, which is indispensable for H3K14 acetylation and for the normal expression of essential genes regulating embryonic development |
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acetylates lysine residues of histones and is involved in DNA replication and gene transcription |
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promotes destabilization of estrogen receptor (ESR1) in breast cancers through lysine 48-linked ubiquitination |