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FLASH GENE
Symbol KAT5 contributors: mct - updated : 01-10-2016
HGNC name K(lysine) acetyltransferase 5
HGNC id 5275
Location 11q13.1      Physical location : 65.479.488 - 65.487.074
Synonym name
  • TAT interactive protein 60 kDa
  • cPLA2 interacting protein
  • HIV-1 Tat interacting protein, 60kDa
  • K-acetyltransferase 5
  • histone acetyltransferase KAT5
  • Synonym symbol(s) TIP60, PLIP, CPLA2, TI60, ESA1, HTATIP1, HTATIP, TIP, ZC2HC5
    EC.number 2.3.1.48
    DNA
    TYPE functioning gene
    STRUCTURE 7.59 kb     14 Exon(s)
    regulatory sequence Promoter
    Binding site   enhancer
    text structure
  • promoter with several E boxes, and expression regulated by the E-box binding circadian transcription factor Clock but not by other E-box binding transcription factors such as c-Myc, Twist, and USF1
  • enhanced the transcriptional activity of Sox9
  • MAPPING cloned Y linked N status confirmed
    Map see MEN1 MEN1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 2229 58.58 513 - 2000 11111051
    13 splicing 2075 52.9 461 nuclear and cytoplasmic 2000 11111051
    lacking exon 5
    13 splicing 2335 61.67 546 - 2003 12801643
  • intron 1 not excised
  • could be differentially regulated and could play different roles than the classical Tip60 protein
  • - - 2191 - 494 - -
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineadrenal gland   highly
    Reproductivefemale systemuteruscervix highly
     male systemtestis  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a HAT domain
  • HOMOLOGY
    interspecies homolog to rattus Htatip (99.80 pc)
    homolog to murine Htatip (99.80 pc)
    intraspecies homolog to esa1
    Homologene
    FAMILY
  • MYST (SAS/MOZ) family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    intracellular,nucleus,nucleolus
    text upon stimulation with EDN1, exported from the nucleus to the perinuclear region
    basic FUNCTION
  • stabilizes NMI through the formation of distinct cytoplasmic speckles provides a new mechanism to modulate NMI-mediated functions
  • histone acetyltransferase implicated in transcriptional control and DNA double-strand break repair
  • downregulates SRSF2 phosphorylation by inhibiting the nuclear translocation of both SRPK1 and SRPK2 kinases
  • recruits MYOD1 on the myogenin promoter, and also increases the levels of acetylated histones H3 and H4 during myogenic differentiation
  • requirement of KAT5-mediated acetylation of ULK1 in serum deprivation–induced autophagy
  • positively regulates ZBTB7B-mediated repression of eomesodermin in human CD4+ T cells
  • plays an essential role in oncogenic RAS-induced senescence
  • KAT5 tyrosine phosphorylation is a key event in the sensing of genomic and chromatin perturbations, with a key role for ABL1 in such processes
  • in embryonic stem cells (ESCs), activates genes required for proliferation and silences genes that promote differentiation
  • CREBBP and KAT5 coordinate histone acetylation at both local and global levels to facilitate RAS-induced transformation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
  • autophagy-activating pathway that comprises GSK3A, GSK3B, KAT5, and ULK1
  • a component
  • with ATM form a stable complex that is recruited to DSBs
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with the NID repeats of NMI, a region essential for the cytoplamic localization and homo- and heterodimerization of NMI
  • interaction between KAT5 and EP400 involving the SANT domain, which binds to the HAT domain of KAT5 and suppresses HAT activity
  • NUT can interact with additional HAT enzymes such as KAT5 and KAT2A to induce the histone hyperacetylation on chromatin
  • role for GPR50 in NR3C1 signalling through interaction with kat5
  • required for myoblast differentiation via enhancement of the transcriptional activity of MYOD1
  • multiple protein-protein interactions by the protein acetyltransferase KAT5 are required for estrogen-induced transcription of a subset of estrogen receptor alpha (ESR1) target genes in cells
  • cooperation of KAT5 with ESR1 and other chromatin-remodeling enzymes is required for estrogen-induced transcription
  • interactions of NRL with c-Jun N-terminal kinase 1 (MAPK8) and HIV Tat-interacting protein 60 (KAT5)
  • SIRT1 deacetylation of the enzymatic domains of KAT8 and KAT5 inhibits their acetyltransferase activity and promotes ubiquitination-dependent degradation of these proteins
  • binds with PAX6 and this physical interaction leads to the full-transcriptional activation of PAX6 during retina development
  • KAT5-mediated CDKN1A acetylation is a novel and essential regulatory process required for CDKN1A-dependent DNA damage-induced cell-cycle arrest
  • ING5 functions as a cofactor of KAT5 in the acetylation of TP53 at K120 in response to DNA damage
  • cascade of posttranslational modifications involving MAPK14, KAT5, and MAPKAPK5, three proteins that are essential for ras-induced senescence
  • is a co-repressor of ZBTB7B-target genes, where ectopically expressed KAT5 increased ZBTB7B protein stability by promoting its acetylation at its Lys(360) residue
  • HDAC6 plays a major role in the modulation of KAT5-EP400 function in stem cells
  • activation of KAT5 by DSBs requires interaction of KAT5 with histone H3 methylated on lysine 9 (H3K9me3)
  • RANBP9-KAT5 interaction dramatically relocated RANBP9 from a widespread cellular distribution to nuclear speckles
  • KAT5 chromodomain was found to facilitate SOX4 recruitment to the CALD1 promoter, which is involved in chromatin remodeling at the promoter
  • PDCD5 participates likely in immune regulation by promoting regulatory T cell function via the PDCD5-KAT5-FOXP3 pathway (
  • cell & other
    REGULATION
    inhibited by ATF2 who promotes degradation of KAT5
    repressed by KDM5B (repress the expression of the KAT5 gene through its H3K4 demethylation on the promoter)
    Other regulated in cells through post-translational modifications or subcellular localisation of the protein
    regulated by sumoylation which augments its acetyltransferase activity
    tyrosine phosphorylation of KAT5 increases after DNA damage in a manner that promotes KAT5 binding to the histone mark H3K9me3
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   LOH    
    frequent target for mono-allelic loss in lymphomas and head-and-neck and mammary carcinomas, with concomitant reduction in mRNA levels
    constitutional     --over  
    in cisplatin-resistant cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS