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FLASH GENE
Symbol JSRP1 contributors: mlc/npt - updated : 11-01-2008
HGNC name junctional sarcoplasmic reticulum protein 1
HGNC id 24963
Location 19p13.3      Physical location : 2.252.249 - 2.256.422
Synonym name
  • homolog of mouse skeletal muscle sarcoplasmic reticulum protein
  • junctional-face membrane protein of 45 kDa homolog
    • Synonym symbol(s) FLJ32416, JP-45, JP45
    DNA
    TYPE functioning gene
    STRUCTURE 4.00 kb     7 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 1173 36.3 331 - Gouadon (2006)
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunespleen    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a cytoplasmic domain
  • a single transmembrane segment
  • an intralumenal domain enriched in positively charged amino acids
    • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    text skeletal muscle sarcoplasmic reticulum
    basic FUNCTION
  • intracellular membrane compartment controling intracellular calcium concentration and therefore playing a role in excitation-contraction coupling
  • involved in the molecular mechanism underlying skeletal muscle excitation-contraction coupling
  • involved in the development or maintenance of skeletal muscle strength
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with the alpha1.1 subunit voltage-gated calcium channel and calsequestrin
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS