Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

JMY

contributors: mct - updated : 23-08-2015

HGNC name	junction-mediating and regulatory protein
HGNC id	28916

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	5q14.1      Physical location : 78.531.924 - 78.623.036
Synonym name	p300 transcriptional cofactor JMY mRNA
	CDNA FLJ37870 fis, clone BRSSN2017682, highly similar to Mus musculus
Synonym symbol(s)	FLJ37870, MGC163496, WHDC1L3, WHAMM2

DNA

TYPE	functioning gene
STRUCTURE	91.11 kb     11 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	Promoter
text structure	contains HIF-responsive elements in its promoter region and HIF1A is recruited to its promoter during hypoxia

MAPPING

cloned

Y

linked

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_152405 11 - 9145 NP_689618 - 988 - 2011 21965285

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive pharynx       moderately Endocrine neuroendocrine pituitary     moderately   parathyroid       highly Hearing/Equilibrium ear inner cochlea   predominantly Nervous brain       highly Homo sapiens   nerve       moderately Respiratory respiratory tract trachea     highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a nuclear export signal
	N-terminal S/T-P motifs
	an central adenovirus E1A CR2-like motif
	a WASP homology 2 domain, connector,
	a acidic region (WWWCA), sufficient to promote actin-based bead motility in cytoplasmic extracts, and this activity depends on its ability to activate the Arp2/3 complex
	two p300-binding domains
	a C-terminal proline-rich region, and C-terminus of JMY comprises a canonical VCA-module, the sequence signature of Arp2/3 complex activators

HOMOLOGY

interspecies

homolog to murine Jmy (90.9 pc)

Homologene

FAMILY

p53 family

CATEGORY

regulatory , protooncogene

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytoskeleton
	intracellular,nucleus
text	in various cell lines JMY is predominantly cytoplasmic, with a minor fraction in the nucleus

basic FUNCTION	inducing growth arrest or apoptosis depending on the physiological circumstances and cell type
	regulating negatively cell division by controlling a set of genes required for this process, like an inhibitor of cyclin-dependent kinases
	may play a role in the apoptosis induction mediated either by stimulation of BAX and FAS antigen expression, or by repression of BCL2 expression
	having two nucleating activities by activating Arp2/3 complex and assembling filaments directly using a Spire-like mechanism (Zuchero, 2009)
	TP53 cofactor that was recently shown to nucleate actin assembly by a hybrid mechanism involving tandem actin monomer binding and Arp2/3 complex activation
	having a function as a modulator of neuritogenesis
	regulator of both transcription and actin filament assembly. In response to DNA damage
	transcriptional co-factor in the TP53-response to DNA damage
	JMY drives vesicular trafficking in the trans-Golgi region and at ER-membrane contact sites (MCS), distinct from other Arp2/3 activators involved in vesicle transport processes
	JMY shows similar localization to WHAMM and could be involved in similar processes.

CELLULAR PROCESS	cell cycle
	cell life, cell death/apoptosis
	nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

text	trans-activator in cell cycle regulation
	transcriptional repression

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	interacts with EP300, which are ubiquitous transcriptional co-activators that interact with a variety of sequence-specific transcription factors, including hypoxia-inducible factor-1alpha (HIF1A)
	accumulates in the nucleus and promotes TP53-dependent apoptosis

cell & other

REGULATION

induced by	DNA damage
		small molecule inhibitors of Mdm2 activity

Other	ubiquitin-dependent degradation promoted by MDM2
	activity is regulated by sequestration in the nucleus
	increased level enhances motility whereas loss of JMY slows cell migration

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS