basic FUNCTION
| receptor for phosphatidylserine (PSR), which facilitates the phagocytosis of dead and dying cells by macrophages and fibroblasts |
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JmjC-containing iron and 2-oxoglutarate-dependent dioxygenase that demethylates histone H3 and histone H4 |
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does not directly function in the clearance of apoptotic cells |
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plays a critical role in organ development and terminal differentiation of many cell types during embryogenesis |
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required for differentiation of organs during embryogenesis |
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lysine hydroxylase that specifically recognizes the protein tail of U2AF2, a mediator of RNA splicing |
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probably acts as a key regulator of hematopoietic differentiation |
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likely has a function as a nonheme-Fe(II)-2-oxoglutarate-dependent dioxygenase |
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has important role in vertebrate development (Webby 2009) |
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may have a role in the regulation of RNA splicing |
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may recognize substrates including nucleic acids in addition to the known peptide tails |
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may function as a component of the splicesome (including U2AF2) at the branch site to affect the alternative splicing of pre-mRNA |
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regulates the splicing of FLT1, thereby controlling angiogenic sprouting |
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may act as a molecular sensor coupling oxygen levels to coordinated endothelial responses in order to meet the metabolic demands of the hypoxic tissues |
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WHSC1L1 as well as JMJD6 is recruited to regulated genes in a BRD4-dependent manner |
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has a binding affinity to histone proteins and hydroxylates multiple lysyl residues of histone H3 and H4 tails |
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novel role for JMJD6 as an oxygen sensor in the human placenta, and alterations in the JMJD6-VHL-HIF1A feedback loop may indirectly contribute to elevated HIF1A found in preeclampsia |
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nuclear protein involved in histone modification, transcription and RNA processing |
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JMJD6 may play a role in regulating the production of FLT1 in the preeclamptic placenta |
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intimate link between JMJD6 and U2AF2 in alternative splicing regulation, which has important implications in development and disease processes |
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catalyze both lysyl hydroxylation and arginyl demethylation on diverse protein substrates |
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is a non-heme Fe(II) 2-oxoglutarate (2OG)-dependent oxygenase with arginine demethylase and lysyl hydroxylase activities |
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JMJD6 is a novel stress granules (SG) component that interacts with G3BP1 complexes, and its expression reduces G3BP1 monomethylation and asymmetric dimethylation at three Arg residues |
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JMJD6 functions directly or indirectly as an arginine demethylase of G3BP1 that promotes SG formation |