basic FUNCTION
| putatively involved in the development of central nervous system |
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acts in cell nuclei and participates in the negative regulation of cell proliferation signaling |
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may play a critical role in transcription factor cascade to regulate expression of heart-specific genes and normal cardiac development (represses NPPA gene expression by inhibiting transcriptional activities of NKX2.5 and GATA4) |
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might control cardiac myocyte proliferation and cardiac morphogenesis by repressing cyclin D1 expression |
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promotes the polycomb repressive complex 2 recruitment to the target genes while inhibiting its histone methyltransferase activity |
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essential for the binding of Polycomb group proteins to target genes and, for the proper differentiation of embryonic stem cells and normal development |
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critical role in regulating Polycomb group function |
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required for the co-recruitment of PRC1 and RNAP to genes that regulate development in ES cells |
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Jarid2 has a critical role in undifferentiated ES cells either in preserving their multi-lineage potential status or in mediating the successful switching of ES cells from a proliferative to a differentiating state |
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potential regulator of NOTCH1 signaling |
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NOTCH1 is a potential target of JARID2 in the endocardium of the developing ventricle |
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required for balancing maintenance and differentiation of stem cells including embryonic and induced pluripotent stem cells |
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critical role in the ventricular endocardium |
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with MTF2, are important regulatory subunits of PRC2 in embryonic stem (ES) cell |
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required for normal cardiac development |
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silences NOCH1 in the late stages of embryonic cardiac development through recruiting SETDB1 to facilitate enrichment of H3K9me2 and H3K9me3 at that locus |