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FLASH GENE
Symbol JAM2 contributors: mct - updated : 24-08-2020
HGNC name junctional adhesion molecule 2
HGNC id 14686
Corresponding disease
BGCI8 basal ganglia calcification, idiopathic, 8, autosomal recessive
Location 21q21.3      Physical location : 27.011.588 - 27.087.235
Synonym name
  • vascular endothelial junction-associated molecule
  • junctional adhesion molecule B
    • Synonym symbol(s) VE-JAM, C21orf43, JAM-B, JAMB, CD322, JAM-IT/VE-JAM, PRO245, IBGC8,
    DNA
    TYPE functioning gene
    STRUCTURE 78.28 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 4357 30.8 298 - 2003 14519386
    9 - 4249 - 262 - 2003 14519386
    10 - 1747 - 312 - 2003 14519386
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   predominantly Homo sapiens
    Lymphoid/Immunelymphatic vessel     Homo sapiensAdult
     tonsils    
    Reproductivefemale systemuterus  highly Homo sapiensAdult
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow    Homo sapiensAdult
    Epithelialbarrier liningendometrium   Homo sapiensAdult
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Cardiovascularendothelial cell Homo sapiensAdult
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two Ig-like folds
  • three N-linked glycosylation site in the extracellular domain
  • a C terminal short tail with a PDZ domain
    • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Jcam2
    Homologene
    FAMILY
  • immunoglobulin superfamily
  • JAM family
    • CATEGORY adhesion
    SUBCELLULAR LOCALIZATION     plasma membrane,junction,tight
    text integral transmembrane protein of tight junction,colocalizing with F actin at membrane ruffles
    basic FUNCTION
  • may be involved in adhesion events associated with cardiac inflammatory conditions
  • JAM1, JAM2, JAM3 expressions on the lymphatic endothelium may contribute to both seal the cell-cell contact at interendothelial junctions
  • play an important role in the assembly and maintenance of tight junctions and in the establishment of epithelial cell polarity
  • identifies a unique population of RGCs (retinal ganglion cells) in which structure corresponds remarkably to function
  • appears to contribute to leucocyte extravasation by facilitating not only transmigration but also rolling and adhesion
  • is an active player in the maintenance of the bone marrow stromal microenvironment
  • JAMB and JAMC are potentially essential for vertebrate myocyte fusion
  • may play a role in the interaction between hatched blastocyst and receptive uterus
  • role of JAM2, JAM3 in progression of gastric adenocarcinoma
  • may function as a putative tumour suppressor in the progression and metastasis of colorectal cancer
  • is an adhesive ligand interacting with various immune cell types and regulating vascular function and was recently identified as an inhibitor of somatodendritic myelination in spinal cord neurons
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS inflammation
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • integrin alpha 4 beta 1 facilitated by JAM3
  • interactions with JAM2 and JAM3 are essential for development of cutaneous inflammation
  • high affinity JAM3 ligand
  • functional adhesive interaction between JAM2 and JAM3 is found between human hematopoietic stem and progenitor cells (HSPC) and mesenchymal stem cells
    • cell & other
  • adhering to T, NK, dendritic cells
    • REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) BGCI8
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --other  
    aberrantly expressed in glioma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerbrain 
    potential of JAM3 and JAM2 as new targets for the treatment of human gliomas
    ANIMAL & CELL MODELS
  • Jam-b-deficient mice have defects in the regulation of hematopoietic stem cell pool