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FLASH GENE
Symbol JAGN1 contributors: mct - updated : 01-04-2015
HGNC name jagunal homolog 1 (Drosophila)
HGNC id 26926
Corresponding disease
SCNP6 neutropenia, severe congenital, 6
Location 3p25.3      Physical location : 9.932.270 - 9.936.029
Synonym symbol(s) GL009, FLJ14602
DNA
TYPE functioning gene
STRUCTURE 3.76 kb     2 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 1660 - 183 - 2005 16303743
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine   
Endocrineadrenal gland    
Reproductivefemale systemuteruscervix highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose   
Connectivebone   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Jagn1 (97.3pc)
Homologene
FAMILY
CATEGORY regulatory
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,membrane
intracellular,cytoplasm,organelle,endoplasmic reticulum
basic FUNCTION
  • new regulator of neutrophil function in microbial pathogenesis
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SCNP6
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • mice carrying a hematopoietic lineage-specific deletion of Jagn1 cannot mount an efficient neutrophil-dependent immune response to the human fungal pathogen Candida albicans