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FLASH GENE
Symbol IWS1 contributors: mct - updated : 23-06-2010
HGNC name IWS1 homolog (S. cerevisiae)
HGNC id 25467
Location 2q14.3      Physical location : 128.238.382 - 128.284.087
Synonym symbol(s) DKFZp761G0123, FLJ10006, FLJ14655, FLJ32319, MGC126375, MGC126376
DNA
TYPE functioning gene
STRUCTURE 45.70 kb     14 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
14 - 3000 - 819 - Yoh (2007)
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus
basic FUNCTION
  • can function as a target for pathway-specific activators, thereby providing a unique mechanism for the control of gene expression (Li 2010)
  • connects two distinct C-terminal domain-binding proteins, SUPT6H and SETD2, in a megacomplex that affects mRNA export as well as the histone modification state of active genes (Yoh 2008)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SUPT6H-interacting protein (Yoh 2007)
  • also recruits the HYPB/Setd2 histone methyltransferase to the RNAPII elongation complex and is required for H3K36 trimethylation (H3K36me3) across the transcribed region of the c-Myc (Yoh 2008)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS